利用动网格技术模拟动脉粥样硬化发展过程

发布时间：2018-04-11 01:21

  本文选题：动脉粥样硬化 + 用户自定义函数　； 参考：《医用生物力学》2017年04期

【摘要】：目的通过在FLUENT计算流体动力学分析软件中调用自主开发的用户自定义函数(user defined function,UDF)动网格程序,实现网格节点根据壁面切应力(wall shear stress,WSS)判据进行移动更新,并将此方法应用于模拟动脉粥样硬化(atherosclerosis,AS)的发展过程中。方法二次开发的UDF程序能够在计算过程中提取壁面各节点处WSS结果,若满足阈值判据条件则进行移动调整。采用弹性光顺与局部重构相结合的网格再生方法调控网格模型的更新,保证变形过程中的网格质量。结果 UDF程序成功提取出WSS并调整网格进行相应变形。初始狭窄造成的尾部涡流导致血管壁出现近端局部扩张,远端再狭窄的形貌特征,临床血管造影存在相似形貌。结论自主开发的UDF程序达到了预期效果,勾勒出了WSS影响下AS的形貌特征。在今后研究中可以考虑在动网格的变形控制方面添加更多影响因素,为AS临床预后及风险评测提供数值依据。
[Abstract]:Aim by calling the self-developed user defined function (UDF) dynamic grid program in the FLUENT computational fluid dynamics analysis software, the grid node can be moved and updated according to the wall shear stress wall shear stress WSS criterion.The method was applied to the development of atherosclerotic ASA.Methods the second developed UDF program can extract the WSS results at every node on the wall in the course of calculation, and adjust the motion if the threshold criterion condition is satisfied.The mesh regeneration method combined with elastic fairing and local reconstruction is used to control the updating of the mesh model to ensure the mesh quality in the process of deformation.Results UDF program successfully extracted WSS and adjusted the mesh for corresponding deformation.The initial stenosis resulted in local dilatation of the proximal end of the vascular wall and the appearance of distal restenosis, and the appearance of clinical angiography was similar.Conclusion the self-developed UDF program achieves the desired effect and outlines the morphological characteristics of as under the influence of WSS.In the future research, we can add more factors to the deformation control of dynamic mesh, and provide the numerical basis for the clinical prognosis and risk assessment of as.
【作者单位】： 郑州大学力学与工程科学学院微纳成型技术国家级国际联合研究中心;
【基金】：国家国际科技合作专项(2015DFA30550) 国家高端外国专家项目(20154100007) 河南省国际科技合作项目(152102410013) 河南省高等学校科研创新团队(14IRTSTHN001)
【分类号】：R543.5;TP393.02
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本文编号：1733806