通过血栓弹力图检测不同温度时人体凝血功能变化的研究分析

发布时间：2017-12-31 06:16

本文关键词：通过血栓弹力图检测不同温度时人体凝血功能变化的研究分析　出处：《中国输血杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的通过调节血栓弹力图仪(TEG)的测试温度来模拟人体体温的变化过程,以了解普通人群在不同体温情况下TEG检测指标的变化,观察其凝血功能的改变。方法抽取47名临床患者(男26名,女21名),年龄范围(19-75岁),枸橼酸钠抗凝全血各2 m L,调节血栓弹力图仪的温度至37℃、38℃、39和40℃,分别对47个血液标本进行血小板普通16项测试,观察血栓弹力图检测参数R、MA、ANGLE和CI值变化情况,研究不同温度条件下标本凝血功能的改变。结果将37℃时的TEG检测指标分别与38℃、39℃、40℃时的检测指标进行两两比较,其中R值配对t检验的P值均为0,ANGLE值配对t检验的P值分别为0、0.001和0,MA值配对t检验的P值分别为0.023、0.003和0.001,CI值配对t检验的P值分别为0、0.04和0,所有P值均0.05。数据统计学处理说明:不同温度下的检测参数R、MA、ANGLE和CI值存在显著性差异。结论人体在体温逐渐升高的情况下做TEG检查,其结果会出现偏差,趋于高凝状态。
[Abstract]:Regulated by Thrombelastogram instrument (TEG) test to simulate the change process of the temperature of the human body, in order to understand the changes of the general population in different temperature conditions TEG detection index, observe the change of the coagulation function. Methods 47 patients (26 male, 21 female, age range (19-75 years)), sodium citrate anticoagulation blood 2 m L, adjust the Thrombelastogram instrument temperature to 37 DEG C, 38 C, 39 C and 40, respectively, 16 common platelet test of 47 blood specimens, observe the Thrombelastogram detection parameters R, MA, ANGLE and CI value changes, the research sample the coagulation function under different temperature changes. Results the TEG detection index at 37 C and 38 C, 39 C, 40 C detection index of 22, which R value of paired t test, P = 0, ANGLE value of paired t test P values were 0,0.001 and 0, MA the value of paired t test P value Don't be 0.023,0.003 and 0.001, CI value of paired t test P values were 0,0.04 and 0, all P values were 0.05. data statistical description: testing parameters of R, the different temperature of MA, there is a significant difference between the ANGLE and CI values. Conclusion the increased in temperature under the condition of TEG examination, the results the deviation, tends to hypercoagulable state.

【作者单位】：空军总医院输血科;
【基金】：“十二五”军队课题面上项目(CKJ13J013):空运输血设备与技术适应性研究
【分类号】：R446.11
【正文快照】： 1948年Hartert博士发明了TEG技术,从80年代中后期至今,国内外对TEG技术的应用越来越广泛[1]。目前,TEG已在40多个国家被广泛应用于冠心病、脑卒中、围术期、创伤救治和成分输血等过程中凝血和纤溶功能的监测。在对通过TEG监测人体温度对于凝血功能的研究国内外报道较少,不过现

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