2011—2015年ICU血培养病原菌分布及耐药性分析

发布时间：2017-12-31 23:27

本文关键词：2011—2015年ICU血培养病原菌分布及耐药性分析　出处：《现代预防医学》2016年17期 　论文类型：期刊论文

更多相关文章： ICU 血培养 病原菌 分布 耐药性

【摘要】：目的了解ICU血培养病原菌的分布及耐药性,为血流感染的经验性治疗提供参考。方法对2011年1月—2015年12月ICU血培养分离的病原菌进行细菌鉴定及药敏分析,使用WHONET 5.4软件进行统计分析。结果 6852份血培养标本中共检测出病原菌323株,阳性率为4.71%;其中革兰阴性菌、革兰阳性菌及真菌占比分别为56.97%,33.43%和9.60%。革兰阴性菌排名前4位依次为肺炎克雷伯菌(14.55%)、鲍曼不动杆菌(13.93%)、洋葱伯克霍尔德菌(7.74%)及大肠埃希菌(4.64%);前4位革兰阳性菌依次为溶血葡萄球菌(6.50%)、表皮葡萄球菌(6.19%)、屎肠球菌(4.02%)及粪肠球菌(3.72%)。肺炎克雷伯菌、大肠埃希菌、鲍曼不动杆菌及洋葱伯克霍尔德菌对亚胺培南的耐药率分别为19.15%、0.00%、60.00%和40.00%。未发现耐万古霉素和利奈唑胺的葡萄球菌及粪肠球菌,但屎肠球菌对利奈唑胺耐药率已达23.08%。结论 ICU血培养分离的病原菌以肠杆菌和非发酵菌为主,大部分呈现高耐药和多药耐药的特点;已出现耐碳青酶烯类的肺炎克雷伯菌及耐利奈唑胺的屎肠球菌,需继续重点监测。
[Abstract]:Objective to investigate the ICU blood culture distribution and antimicrobial resistance of pathogenic bacteria, to provide reference for empiric treatment of bloodstream infection. Methods bacterial identification and drug susceptibility analysis of pathogenic bacteria culture from January 2011 to December 2015 ICU blood, using WHONET 5.4 software for statistical analysis. Results 6852 blood specimens were detected in 323 strains of pathogenic bacteria, positive the rate is 4.71%; the gram negative bacteria, gram positive bacteria and fungi accounted for 56.97%, 33.43% and 9.60%. of gram negative bacteria in the top 4 were Klebsiella pneumonia (14.55%), Bauman Acinetobacter (13.93%), Burke Holder (7.74%) onion bacteria and Escherichia coli (4.64%); the top 4 gram positive bacteria were Staphylococcus haemolyticus (6.50%), Staphylococcus epidermidis (6.19%), Enterococcus faecium and Enterococcus faecalis (4.02%) (3.72%), Klebsiella pneumoniae, Escherichia coli, Acinetobacter Bauman and Burke Holzer of the onion De bacteria to imipenem were 19.15%, 0%, 60% and 40.00%. were found in Staphylococcus aureus and Enterococcus faecalis resistant to vancomycin and linezolid, but Enterococcus faecium to linezolid resistance rate has reached 23.08%. conclusion ICU blood culture pathogenic bacteria isolated from Escherichia coli and non fermenting bacteria, most of them show features high resistance and multi drug resistance has emerged; the carbapenem resistant Klebsiella pneumoniae and linezolid resistant Enterococcus faecium, need to continue to focus on monitoring.

【作者单位】：南京医科大学附属无锡市人民医院;
【基金】：无锡市科技发展基金(CSE31N1503)
【分类号】：R446.5
【正文快照】： 血流感染所致菌血症、败血症等是引起患者急性死亡的原因之一[1],亦是ICU患者非心源性死亡的主要致死原因之一[2]。本研究回顾性分析2011年1月—2015年12月ICU患者血培养标本病原菌的分布及耐药性特点,以了解本院ICU患者血流感染的现状及耐药性,为临床经验性抗感染治疗提供参

【相似文献】