急性胆管炎患者胆汁病原菌分布与药敏性分析

发布时间：2018-01-01 00:20

本文关键词：急性胆管炎患者胆汁病原菌分布与药敏性分析　出处：《中华医院感染学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的了解急性胆管炎患者胆汁病原菌分布及药敏性,为正确选择抗菌药物治疗提供依据。方法选取2009年6月-2015年6月于医院治疗的急性胆管炎患者145例,采集患者胆汁标本采用WITEK-2Compact进行菌种鉴定,药敏试验采用K-B纸片扩散法进行,数据采用SPSS15.0进行统计分析。结果 145例患者共送检胆汁标本195份,培养出病原菌158株,其中革兰阳性菌58株占36.71%,革兰阴性菌95株占60.13%,真菌5株占3.16%;革兰阳性菌对替考拉宁、亚胺培南、万古霉素的敏感性较高均在75.00%以上,对青霉素G、阿奇霉素、氧氟沙星的敏感性低;革兰阴性菌对哌拉西林、美罗培南、亚胺培南、阿米卡星敏感性高均在75.00%以上,对氨苄西林、头孢噻肟、氨曲南敏感性低;真菌对酮康唑、氟康唑、伊曲康唑及伏立康唑的敏感性均为100.00%。结论急性胆管炎患者感染的主要病原菌是革兰阴性菌,革兰阳性菌和革兰阴性菌对常用抗菌药的敏感性有一定程度的下降,临床应根据药敏试验结果选用合理的抗菌药物。
[Abstract]:Objective to investigate the pathogenic bacteria distribution of bile in patients with acute cholangitis and drug sensitivity, which provides a basis for the correct selection of antibiotics in the treatment of 145 patients with acute cholangitis. Methods -2015 June in hospital from June 2009 were collected in patients with bile specimens by WITEK-2Compact identification, drug sensitivity test was done by K-B disk diffusion method, using SPSS15.0 statistical data results a total of 145 patients from 195 bile samples, cultured 158 strains of pathogens, including 58 strains of gram positive bacteria accounted for 36.71%, 95 strains of gram negative bacteria accounted for 60.13%, 5 strains of fungi accounted for 3.16%; gram positive bacteria to imipenem and teicoplanin, vancomycin sensitivity was above 75%. Azithromycin for penicillin G, ofloxacin, low sensitivity; gram negative bacteria resistant to piperacillin, imipenem, meropenem, Amikacin high sensitivity was above 75%, the Ampicillin, cefotaxime, aztreonam low sensitivity; fungi to fluconazole, ketoconazole, itraconazole and voriconazole sensitivity were the main pathogenic bacteria infection in patients with acute cholangitis 100.00%. conclusion is gram negative bacteria, gram positive bacteria and gram negative bacteria sensitivity to commonly used antimicrobial drugs have a certain degree of decline, clinical according to the reasonable selection of antimicrobial susceptibility test results.

【作者单位】：南阳医学高等专科学校第一附属医院普外三科;南阳市第三人民医院普外科;
【基金】：河南省重点科技攻关基金资助项目(122102310103)
【分类号】：R446.5
【正文快照】： 急性胆管炎患者发生感染的主要原因是由于各种发病因素导致胆管不同部位的梗阻[1]。患者感染后会出现发热、腹痛、黄疸及寒战等症状,甚至出现休克,有研究报道,急性胆管炎患者病死率约20.00%。在临床上一旦怀疑或者确诊急性胆管炎,应尽早进行抗感染治疗,而合理的选择抗菌药物对

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