2005—2014年CHINET铜绿假单胞菌耐药性监测

发布时间：2018-01-07 02:00

本文关键词：2005—2014年CHINET铜绿假单胞菌耐药性监测　出处：《中国感染与化疗杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的了解2005-2014年中国不同地区铜绿假单胞菌临床分离株的耐药性和耐药特征,指导临床合理使用抗菌药物。方法对全国19所医院临床分离的铜绿假单胞菌按照统一的方案、采用统一的材料、方法(K-B法)和判断标准,进行铜绿假单胞菌的耐药性监测,并用WHONET 5.6软件进行数据分析。结果 10年间从临床标本中共收集54 196株铜绿假单胞菌,其中90.3%菌株分离自住院患者,70.6%分离自呼吸道标本。10年间,铜绿假单胞菌的检出率总体呈下降趋势:2005年为10.2%,2014年下降至9.5%。铜绿假单胞菌对阿米卡星的耐药率最低,为14.1%。分离自门诊的菌株对各抗菌药物的敏感率在57.4%~83.7%,分离自住院非ICU的菌株对各抗菌药物的敏感率在50.5%~81.8%,而分离自ICU的菌株对各抗菌药物的敏感率为38.5%~75.9%。分离自老年患者的菌株对各抗菌药物的敏感率在45.7%~80.9%,成人患者为49.8%~80.4%,儿童患者为66.0%~91.5%。泛耐药铜绿假单胞菌的检出率平均为1.7%。结论临床分离的铜绿假单胞菌对抗菌药物的耐药率仍处于较高水平,但近年耐药率增长趋势稳定。分离自不同年龄、标本类型及科室的菌株对抗菌药物的耐药性相差较大,医疗机构应加强细菌耐药监测,指导临床合理使用抗菌药物。同时要加强感染控制措施,预防和控制耐药菌株的医院内流行。
[Abstract]:Objective to investigate the 2005-2014 Chinese clinical isolates of Pseudomonas aeruginosa in different areas of resistance and resistance characteristics, to guide the rational use of antibiotics. Methods the clinical isolates of 19 hospitals in the country of Pseudomonas aeruginosa in accordance with the unified plan, the unified material method (K-B method) and the judgment standard, monitoring of drug resistance of Pseudomonas aeruginosa this bacterium, and the data were analyzed with WHONET 5.6 software. Results 10 years from clinical specimens were collected 54196 strains of Pseudomonas aeruginosa, 90.3% strains isolated from hospitalized patients, 70.6% isolated from respiratory tract specimens from.10, Pseudomonas aeruginosa and the detection rate of the overall downward trend: in 2005 10.2%, down to 2014 9.5%. of Pseudomonas aeruginosa resistant to Amikacin was the lowest, 14.1%. isolated from clinic strains on the sensitive rate of the antibacterials in 57.4%~83.7%, isolated from non ICU hospital Strains on the sensitive rate of the antibacterials in 50.5%~81.8%, and isolated from ICU strain on the sensitive rate of the antibacterials for elderly patients with 38.5%~75.9%. isolated from strains on the sensitive rate of the antibacterials in adult patients with 45.7%~80.9%, 49.8%~80.4%, 66.0%~91.5%. for children with Pan resistant Pseudomonas aeruginosa detection rate of Pseudomonas aeruginosa conclusion the clinical isolates of Pseudomonas aeruginosa 1.7%. on drug resistance rates remained at a high level, but in recent years a steady growth trend. The resistance rate of isolates from different ages, specimen type and sections of the strains to antimicrobial resistance is large, the medical institutions should strengthen the monitoring of bacterial resistance and to guide the rational use of antibiotics at the same time to strengthen. Infection control measures to prevent and control the nosocomial epidemic of drug-resistant strains.

【作者单位】：上海交通大学医学院附属瑞金医院;浙江大学医学院附属邵逸夫医院;浙江大学附属第一医院;北京协和医院;华中科技大学同济医学院附属同济医院;复旦大学附属华山医院;复旦大学附属儿科医院;广州医科大学附属第一医院;北京医院;重庆医科大学附属第一医院;新疆医科大学第一附属医院;上海交通大学附属儿童医院;甘肃省人民医院;安徽医科大学第一附属医院;昆明医科大学第一附属医院;天津医科大学总医院;四川大学华西医院;内蒙古医科大学附属医院;中国医科大学附属第一医院;
【分类号】：R446.5
【正文快照】： 铜绿假单胞菌因为细胞膜通透障碍而天然耐质控菌株为铜绿假单胞菌ATCC27853。药敏试验多种抗菌药物,加之其获得性耐药,同时又易在按CLSI 2014年标准判断结果,并用WHONET5.6医院内各种潮湿环境中生存,而成为医院感染常软件进行数据分析。见、难治疗的革兰阴性杆菌之一。2结果为

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