臂旁核神经元调节睡眠觉醒的研究进展

发布时间：2018-01-08 02:29

本文关键词：臂旁核神经元调节睡眠觉醒的研究进展　出处：《中国药理学通报》2016年06期 　论文类型：期刊论文

【摘要】：臂旁核(parabrachial nucleus,PB)是环绕在脑桥结合臂周围的灰质结构,主要由谷氨酸、γ-氨基丁酸(γ-aminobutyric acid,GABA)和脑啡肽神经元组成。PB与下丘脑、基底前脑等觉醒核团有着广泛的神经纤维联系,特异性损毁PB可引起动物昏迷样症状。同时,PB向非快动眼(non-rapid eye movement,NREM)睡眠核团腹内侧视前区投射,并接受来自面旁核的投射,激活面旁核中的GABA能神经元可促进NREM睡眠,表明PB可能参与NREM睡眠的调控。此外,快动眼(rapid eye movement,REM)睡眠剥夺会引起臂旁外侧核的兴奋。综上所述,PB在机体调节觉醒、NREM和REM睡眠中发挥着重要作用。该文将就PB在睡眠-觉醒调节作用中的研究进展做一综述。
[Abstract]:The parabrachial nucleus (parabrachial nucleus PB) is surrounded by combining the gray matter structure around the arm in the pons, mainly by glutamate, GABA (gamma -aminobutyric acid, GABA) and enkephalin neurons.PB and hypothalamus, basal forebrain nuclei have other awakening nerve fiber connections, specific damage PB cause animal coma like symptoms. At the same time, PB to non REM (non-rapid eye movement, NREM) sleep intra-abdominal nucleus preoptic area projection, and receive from the projection surface of the paraventricular nucleus, the paraventricular nucleus of the surface activation of GABA neurons can promote NREM sleep, showed that PB could regulate NREM sleep. In addition, fast REM (rapid eye movement, REM) sleep deprivation can excite the lateral parabrachial nucleus. In summary, PB in regulating arousal, plays an important role in NREM and REM. The PB will sleep in sleep wake regulation of the A Overview.

【作者单位】：皖南医学院药理学教研室;复旦大学基础医学院药理学系;
【基金】：国家自然科学基金面上项目(No 81571295)
【分类号】：R740
【正文快照】： 人生的三分之一在睡眠中度过,睡眠相分为快动眼(rapid eye movement,REM)睡眠和非快动眼(non-rapid eyemovement,NREM)睡眠,所有的哺乳动物、鸟类和爬行动物都需要睡眠。睡眠不仅仅是正常的生理行为,更是保障精力充沛的先决条件。当今社会,随着经济发展和竞争压力的增大,睡眠

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