同种抗体特异性不明确的81名患者血清学特征分析及红细胞输注效果评价

发布时间：2018-01-08 13:24

本文关键词：同种抗体特异性不明确的81名患者血清学特征分析及红细胞输注效果评价　出处：《中国输血杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的对存在特异性不明确的同种抗体患者,通过分析血清学特征及评估红细胞输注效果,评价配血方法的安全性。方法回顾性分析本院2013-2014年度不规则抗体筛查阳性且血清学方法无法明确抗体特异性的患者139例,并应用临床输血智能管理与评估系统对81例输注红细胞的患者进行效果评价。结果 139例患者中,抗体类型分5种,效价低、活性弱抗体占多数。139例患者中红细胞输注81例,输注红细胞114次。其中输注有效率77.2%;部分有效率22.8%;输注无效率0%。不同类型抗体输注有效率与部分有效率无显著性差异(P0.05)。81例输注红细胞患者中,男性34例,有输血史者19例(55.9%);女性47例,有输血史者43例(91.5%)。所有输血病例均无溶血性输血反应发生。结论红细胞输注前,不规则抗体筛查是必要的,尤应注意有输血史病例。即使血清学方法无法明确抗体特异性,必须同时用盐水法和微柱凝胶法做交叉配血试验,选择相合的血液输注。避免红细胞输注无效、输血不良反应的发生,节约血液资源,提高输血安全。
[Abstract]:The purpose of the same patient specific antibodies are not clear, through the analysis and evaluation of effectiveness of red blood cell transfusion serological characteristics, safety evaluation of matching methods. Methods a retrospective analysis of our hospital 2013-2014 irregular antibody screening positive and serological methods is not clear and specific antibodies in patients with 139 cases, and the clinical application of blood transfusion intelligent management and the evaluation system of 81 cases of red blood cell transfusion patients were evaluated. Results in 139 patients, type 5 antibody titer, low activity, weak antibodies accounted for the majority of.139 patients in 81 cases of red blood cell transfusion, infusion of red blood cells 114 times. The infusion rate was 77.2%; effective part 22.8%; transfusionrefractoriness rate of 0%. of different types of antibody infusion efficiency and efficiency have no significant difference (P0.05).81 cases of red blood cell transfusion patients, 34 cases were male, 19 cases had history of blood transfusion (55.9%); 47 cases were female, has a history of blood transfusion 43 cases (91.5%). All cases had no blood transfusion hemolytic transfusion reactions. Conclusion the red cell infusion, irregular antibody screening is necessary, especially should pay attention to the history of blood transfusion cases. Even serological methods can not clear the antibody specificity, must at the same time with saline water method and microcolumn gel cross match test choose, matched blood transfusions. Red blood cell transfusion to avoid invalid, the occurrence of adverse transfusion reactions, save blood resources, improve the safety of blood transfusion.

【作者单位】：中国人民解放军总医院输血科;
【基金】：“十三五”全军后勤科研项目子课题(BWS16J006)
【分类号】：R457.11
【正文快照】： 由于输血后或妊娠后患者具有同种抗体免疫的潜在风险,有报道长期输血的患者,14%-50%的个体可能产生同种免疫反应。血清学检测若未能发现抗体存在,输血后诱导潜在抗体与相应抗原发生免疫反应,出现红细胞输注无效、迟发型溶血性输血反应,并且会加重原发病甚至威胁生命。所以应重

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