乳腺癌MRI强化特征与免疫组织化学相关性分析

发布时间：2018-01-09 20:05

本文关键词：乳腺癌MRI强化特征与免疫组织化学相关性分析　出处：《临床放射学杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨乳腺癌MRI强化特征与乳腺免疫组织化学之间的内在联系。方法搜集经病理及免疫组织化学证实的85例乳腺癌患者,均行乳腺动态增强MRI检查,按照乳腺影像报告和数据系统(BI-RADS)描述病灶MRI强化特征,分析其与ER、PR、Her-2、Ki-67表达的相关性。结果乳腺癌病灶MRI强化类型、强化形态、强化边缘与ER、PR、Ki-67的表达具有统计学意义,与Her-2的表达无统计学意义;病灶内部强化特征与Ki-67的表达具有统计学意义,与ER、PR、Her-2的表达无统计学意义;病灶时间-信号强度曲线与ER、Ki-67的表达具有统计学意义,与PR、Her-2的表达无统计学意义。结论乳腺癌的MRI强化特征与免疫组织化学标记物的表达存在一定的关联,从影像角度评估乳腺癌的生物学行为和预后有一定的参考价值。
[Abstract]:Objective to investigate the relationship between MRI breast cancer and breast enhancement characteristics of immunohistochemistry. Methods 85 cases with breast cancer confirmed by pathology and immunohistochemistry, underwent breast dynamic enhanced MRI examination, according to breast imaging reporting and data system (BI-RADS) to describe MRI lesions enhanced features, analysis of the ER and PR. Her-2, the correlation between the expression of Ki-67. The results of breast cancer were MRI intensive type, strengthen the form, strengthen the edge and ER, PR, Ki-67 expression was statistically significant, no statistical significance and expression of Her-2; enhancement within the lesions characteristic has statistical significance, and the expression of Ki-67 and ER, PR, Her-2 expression was not statistically significant focus; the time signal intensity curve and ER, with statistical significance, the expression of Ki-67 and PR, was not statistically significant. Conclusion the expression of Her-2 in breast cancer MRI expression enhancement features and immunohistochemical markers There is a certain correlation. It has a certain reference value to evaluate the biological behavior and prognosis of breast cancer from the image angle.

【作者单位】：苏州大学附属第一医院影像科;南京医科大学附属淮安第一医院MRI室;南京医科大学附属淮安第一医院病理科;
【分类号】：R737.9;R445.2
【正文快照】： 在全球范围内,乳腺癌在所有恶性肿瘤中占22%[1],具有较高的发病率及死亡率,严重影响到女性的健康。当乳腺癌初治肿瘤10 mm时,20年生存率95%[2],因此乳腺癌的早期诊断至关重要。在乳腺癌的各种影像检查中,MRI具有最高的敏感性,一些研究显示乳腺MRI特点可间接反映肿瘤的增殖和

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