烧伤科中心静脉导管相关感染病原菌分布及耐药分析
发布时间:2018-01-11 14:36
本文关键词:烧伤科中心静脉导管相关感染病原菌分布及耐药分析 出处:《中国病原生物学杂志》2016年01期 论文类型:期刊论文
【摘要】:目的探讨中心静脉导管技术在烧伤科应用过程中造成感染的因素、病原菌分布和耐药情况,为烧伤科临床中心静脉导管感染预防和治疗提供依据。方法选取2011年1月-2014年12月烧伤科就诊住院并行中心静脉导管患者1 326例资料,98例出现中心静脉导管相关感染。抽取外周静脉血及导管内血进行培养,鉴定菌株并进行药敏试验。结果 1 326例中心静脉导管治疗患者中98例感染,感染率7.39%。其中男性感染率7.33%(71/969),女性感染率7.56%(21/357)。年龄50岁、≥50岁者感染率分别为5.77%(42/728)和9.36%(56/598);穿刺部位为锁骨下静脉者、穿刺颈内静脉者和穿刺股静脉者感染率分别为7.03%(43/612)、7.18%(37/515)和9.05%(18/199);导管留置时间20d、≥20d者感染率分别为5.60%(46/821)和10.30%(52/505);住院时间45d、≥45d者感染率分别为4.98%(38/763)和9.05%(60/663);各组间感染率差异均有统计学意义(χ2年龄=6.200,χ2穿刺部位=4.5210,χ2留置时间=10.0661,χ2住院时间=9.1791,P均0.05)。分离出103株病原菌,其中革兰阴性菌48株(占46.60%),革兰阳性菌44株(占42.72%),真菌19株(占18.45%)。金黄色葡萄球菌检出最多,共21株(占20.39%),其次为铜绿假单胞菌(18株)。铜绿假单胞菌对青霉素、庆大霉素耐药率分别为66.67%和61.11%,未发现亚胺培南耐药株;大肠埃希菌和金黄色葡萄球菌对青霉素、庆大霉素、美罗培南和亚胺培南耐药率分别为62.50%、62.50%、11.11%、11.11%和71.43%、61.90%、4.76%、4.76%;未发现耐万古霉素金黄色葡萄球菌。讨论患者年龄、穿刺部位、留置时间和住院时间与中心静脉导管引发血流感染密切相关,分离病原菌以革兰阳性和革兰阴性杆菌为主,临床用药要参考药敏结果,以避免耐药菌株产生。
[Abstract]:Objective to investigate the factors causing infection, the distribution of pathogenic bacteria and drug resistance during the application of central venous catheter technique in burn department. Methods 1 326 inpatients with central venous catheter from January 2011 to December 2014 were selected for the prevention and treatment of central venous catheter infection in burn department. 98 cases were infected with central venous catheter. Peripheral and intraductal blood were collected for culture. Results among the 1 326 patients treated with central venous catheter, 98 cases were infected, the infection rate was 7.39%, and the male infection rate was 7.33% 969%. The female infection rate was 7.56 / 3570.The infection rate was 5.7742 / 728 for those aged 50 years and 鈮,
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