细菌与真菌感染对血小板的影响研究

发布时间：2018-01-13 14:32

本文关键词：细菌与真菌感染对血小板的影响研究　出处：《中华医院感染学杂志》2016年22期 　论文类型：期刊论文

【摘要】：目的探讨细菌、真菌感染对血小板的影响,为临床感染性疾病诊断、病情评估、预防治疗提供试验依据。方法选择2011年7月-2015年12月医院收治的感染性疾病患者160例为试验组,其中细菌感染123例、真菌感染37例;另选择同期健康体检者100名为对照组,比较血小板参数,包括血小板数目、血小板平均体积(MPV)、血小板压积(PCT)、血小板体积分布宽度(PDW)四项的变化,从而探讨细菌、真菌感染对血小板的影响。结果试验组患者均出现血小板数量减低、MPV增大、PCT减低、PDW增大,与对照组比较,差异均有统计学意义(P0.05),且革兰阴性杆菌、真菌感染血小板以上参数变化更明显;革兰阳性杆菌、革兰阳性球菌、革兰阴性杆菌、真菌在血小板数目、PCT、MPV、PDW的相互比较中,均差异有统计学意义(P0.05);各试验组血小板数目与MPV均呈显著负相关。结论细菌、真菌感染会造成血小板数量减低、MPV增大、PCT减低、PDW增大,血小板计数简便易操作,能较正确、敏感地反映出感染状态,可借助血小板计数及相关参数检测来辅助判定感染类型,为临床感染性疾病的诊断及鉴别诊断提供有效参数。
[Abstract]:Objective to investigate the effect of bacterial and fungal infection on platelets for clinical diagnosis and evaluation of infectious diseases. Methods from July 2011 to December 2015, 160 patients with infectious diseases were selected as experimental group, including 123 patients with bacterial infection. 37 cases of fungal infection; Another 100 healthy persons were selected as control group. Platelet parameters, including platelet number, mean platelet volume, platelet volume, and platelet compression test (PCT) were compared. The changes of platelet volume distribution width (PDW) were used to investigate the effect of bacterial and fungal infection on platelet. Results in the test group, the platelet count decreased and MPV increased and PCT decreased. Compared with the control group, PDW increased, the difference was statistically significant (P 0.05), and Gram-negative bacilli, fungal infection of the above parameters of platelets was more obvious. Gram-positive bacilli, Gram-positive cocci, Gram-negative bacilli and fungi were all significantly different in the number of platelets and the number of platelets (P 0.05). Conclusion bacterial and fungal infection can result in the increase of platelet count and the increase of MPV, and the platelet count is simple and easy to operate. It can accurately and sensitively reflect the infection state and can be used to determine the type of infection by means of platelet count and related parameters, which can provide effective parameters for the diagnosis and differential diagnosis of clinical infectious diseases.
【作者单位】：华北理工大学附属医院检验科;
【基金】：河北省科技厅指令计划基金资助项目(12276104D-38)
【分类号】：R446.1
【正文快照】： 菌血症作为细菌入血引起的全身炎症反应,具有高发病率、病死率以及临床诊断率低的特点,已成为ICU患者死亡的一个主要原因,对感染病原体的早期识别及合理应用抗菌药物可明显减少细菌耐药,改善预后、降低病死率。目前,对细菌、真菌感染的研究仍多以白细胞变化为中心,尽管危重病

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