蚌埠市维持血液透析患者钙磷代谢及全段甲状旁腺激素控制情况横断面调查

发布时间：2018-01-16 05:20

本文关键词：蚌埠市维持血液透析患者钙磷代谢及全段甲状旁腺激素控制情况横断面调查　出处：《安徽医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的了解蚌埠市维持性血液透析患者钙磷代谢及全段甲状旁腺激素(intact parathyroid hormone,i PTH)控制情况。方法问卷调查蚌埠市蚌埠医学院第一、第二附属医院血液透析治疗大于3个月的患者,记录患者一般人口学资料、原发病、合并症、血液透析方式、透析频率、透析龄,测定血清钙、磷及i PTH水平。以2003年KDOQI CKD-MBD指南为依据,分析维持性血液透析患者校正血钙、血磷、钙磷乘积和i PTH达标率;同时分析血清i PTH水平与血红蛋白(hemoglobin,Hb)、血钙、血磷、钙磷乘积等临床资料相关性;并分析骨代谢异常并发临床症状组与无临床症状组、糖尿病肾病组与非糖尿病肾病组临床资料有无差异。结果本研究纳入170例维持性血液透析患者,校正血钙、血磷、钙磷乘积和i PTH的达标率分别为44.7%、44.1%、71.3%和27.6%,上述四项均达标仅5.8%。血清i PTH水平与年龄、血红蛋白(Hb)及血钙水平呈负相关,与血肌酐水平呈正相关。临床症状组与无临床症状组相比,血钙、血磷、钙磷乘积及i PTH均无统计学差异。与非糖尿病肾病组相比,糖尿病肾病组i PTH水平低(P=0.014)及血磷较低(P=0.003),但血钙及钙磷乘积(P0.05)无差异。结论蚌埠市维持性血液透析患者血清钙、磷及i PTH控制不理想;低血钙、低血红蛋白水平可能是i PTH升高的危险因素。
[Abstract]:Objective to understand the Bengbu city to maintain the calcium phosphorus metabolism in hemodialysis patients and intact parathyroid hormone (intact parathyroid hormone, I PTH). The control method of questionnaire survey of Bengbu Medical College in Bengbu city the first, the Second Affiliated Hospital of hemodialysis for more than 3 months were recorded in patients with general demographic data, primary disease, complications, blood dialysis and the frequency of dialysis, dialysis age, serum calcium, phosphorus and I level of PTH. In 2003 KDOQI CKD-MBD guidelines as the basis, analysis of patients with maintenance hemodialysis corrected serum calcium, serum phosphorus, calcium and phosphorus product compliance rate and I PTH; and I analysis of serum PTH levels and hemoglobin (hemoglobin, Hb), blood calcium, blood phosphorus the clinical data, the calcium phosphorus product correlation; and analysis of the patients with abnormal bone metabolism clinical symptom group and asymptomatic group, diabetic nephropathy group had no difference with non diabetic nephropathy group. Results the clinical data The study included 170 cases of hemodialysis patients, correction of calcium, phosphorus, calcium phosphorus product and I PTH compliance rates were 44.7%, 44.1%, 71.3% and 27.6%, the four were only 5.8%. I serum PTH levels and age, hemoglobin (Hb) were negatively correlated and positively correlated with the blood calcium level. Creatinine levels. The clinical symptoms compared with asymptomatic group of calcium, phosphorus, calcium and phosphorus product were no significant difference between I and PTH. Compared with non diabetic nephropathy group, diabetic nephropathy group I low levels of PTH (P=0.014) and low phosphorus (P=0.003), but the level of serum calcium and calcium phosphorus product (P0.05) no difference. Conclusion Bengbu maintaining blood dialysis patients serum calcium, phosphorus and I PTH control is not ideal; low calcium, low hemoglobin level may be a risk factor of I PTH increased.

【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R692.5

【参考文献】