临床分离金黄色葡萄球菌的药物敏感性分析

发布时间：2018-01-16 21:47

本文关键词：临床分离金黄色葡萄球菌的药物敏感性分析　出处：《中华医院感染学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的调查金黄色葡萄球菌在临床标本中的分布及对抗菌药物的敏感性,为临床医师预防感染、选择药物提供可靠的参考依据。方法收集2013年1-12月临床科室送检标本中分离的480株金黄色葡萄球菌,采用法国生物梅里埃公司VITEK-2全自动微生物分析系统进行药敏试验;采用SPSS15.0软件进行统计分析。结果 480株金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)108株占22.5%,甲氧西林敏感金黄色葡萄球菌(MSSA)372株占77.5%;痰标本MRSA检出率最高,达82.1%,其次为尿液、血液、引流液、皮肤组织,检出率分别为42.9%、21.2%、16.9%和10.4%;未发现耐万古霉素和利奈唑胺金黄色葡萄球菌,金黄色葡萄球菌对磺胺甲VA唑/甲氧苄啶、呋喃妥因和利福平的敏感率较高,皮肤组织来源的MRSA对庆大霉素、环丙沙星、左氧氟沙星、利福平、莫西沙星和四环素的敏感率明显高于其他标本来源的MRSA(P0.05);皮肤组织来源的MRSA对红霉素、克林霉素和磺胺甲VA唑/甲氧苄啶的敏感率明显低于其他标本来源的MRSA(P0.05);MRSA对青霉素的耐药率为100.0%。结论金黄色葡萄球菌是临床感染标本中的重要病原菌,耐药率高,临床医师应根据药敏试验结果合理使用抗菌药物。
[Abstract]:Objective to investigate the distribution of Staphylococcus aureus in clinical specimens and its sensitivity to antimicrobial agents in order to prevent infection for clinicians. Methods 480 strains of Staphylococcus aureus isolated from clinical samples from 2013 to December were collected. The drug sensitivity test was carried out with the VITEK-2 automatic microbiological analysis system of Bio-Merriere Company of France. Results 22.5% of the 480 strains of Staphylococcus aureus were methicillin-resistant Staphylococcus aureus. Methicillin-sensitive Staphylococcus aureus (MSSA) 372 strains accounted for 77.5%; The detection rate of MRSA in sputum was the highest (82.1%), followed by urine, blood, drainage fluid and skin tissue. The detection rate was 42.9% and 10.4%, respectively. Vancomycin resistant staphylococcus aureus and rifampicin were not found. Staphylococcus aureus was sensitive to sulfamethazol / trimethoprim furantoin and rifampicin. The sensitivity of skin tissue derived MRSA to gentamicin, ciprofloxacin, levofloxacin, rifampicin, moxifloxacin and tetracycline was significantly higher than that of other specimens. The sensitivity of skin tissue derived MRSA to erythromycin, clindamycin and sulfamethazol / trimethoprim was significantly lower than that of other specimens. The resistance rate of MRSA to penicillin was 100.00.Conclusion Staphylococcus aureus is one of the most important pathogens in clinical infection, and the drug resistance rate is high. The clinician should use antibiotics reasonably according to the results of drug sensitivity test.
【作者单位】：开封市中心医院检验科;河南省淮河医院检验科;
【基金】：河南省卫生厅基金资助项目(2010ZRZD05)
【分类号】：R446.5
【正文快照】： 随着β-内酰胺类抗菌药物在临床上的广泛应用,耐甲氧西林金黄色葡萄球菌(MRSA)在金黄色葡萄球菌中所占比例逐年上升,MRSA不仅具有严2　结　果重的耐药性,而且不同地区、不同时期、不同医院,其耐药性也各不相同[1-2]。为了探讨医院金黄色葡萄2.1　不同标本MRSA检出率　从480

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