维持性血液透析及腹膜透析患者骨密度的评估

发布时间：2018-01-27 01:53

本文关键词： 慢性肾脏病维持性血液透析腹膜透析超声骨密度仪骨量异常骨密度　出处：《中国骨质疏松杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的了解我院MHD及PD患者BMD状况,探讨BMD与临床资料、骨代谢指标及生化指标的相关性及危险因素分析。方法选择我院住院及门诊随访的MHD及PD患者,透析龄均超过3个月,收集患者临床资料及血尿标本。采用超声骨密度仪检测患者BMD状况,对骨量异常患者的BMD及患者一般临床及实验室资料进行相关性分析,并进一步分析透析患者骨量异常的危险因素。采用SPSS19.0软件包进行数据统计及分析。结果 MHD组及PD组骨量异常发生率分别为57.98%,48.54%,有显著统计学差异;随着透析龄的延长,透析患者BMD下降,透析龄3年以上的PD患者比MHD患者的TScore值相对较高,两组间也存在统计学差异。高龄、高透析龄、高BMI、高血磷及高ALP血症是透析患者发生骨量异常的危险因素。结论 MHD患者比PD患者更易发生骨量异常,且随着透析龄的延长,透析患者骨量异常发生率增高,高龄、高透析龄、高BMI、高血磷及高ALP血症是透析患者发生骨量异常的危险因素。
[Abstract]:Objective to investigate the BMD status of patients with MHD and PD in our hospital and to explore the BMD and clinical data. Methods the patients with MHD and PD who were followed up in our hospital and outpatient department were divided into two groups: the age of dialysis was more than 3 months. The clinical data and blood and urine samples were collected. The BMD status of patients with abnormal bone mass was detected by ultrasound bone mineral density analyzer. The correlation between BMD and general clinical and laboratory data of patients with abnormal bone mass was analyzed. The risk factors of abnormal bone mass in dialysis patients were further analyzed. The data were analyzed by SPSS19.0 software package. The incidence of abnormal bone mass in MHD group and PD group was 57.98%. 48.54, there was significant difference; With the prolongation of dialysis age, the BMD of dialysis patients decreased. The TScore value of PD patients over 3 years of dialysis age was higher than that of MHD patients, and there was statistical difference between the two groups. High BMI, high blood phosphorus and high ALP are the risk factors of abnormal bone mass in dialysis patients. Conclusion MHD patients are more likely to have abnormal bone mass than PD patients, and with the prolongation of dialysis age. The incidence of abnormal bone mass was increased in dialysis patients. The risk factors of abnormal bone mass were elderly, high dialysis age, high BMI, high blood phosphorus and high ALP.
【作者单位】：山东省临沂市人民医院肾内二科;山东省临沂市人民医院老年病科;
【基金】：山东省临沂市科技发展计划项目(201515003)
【分类号】：R459.5
【正文快照】： 最新的流行病学表明,在慢性肾脏病(chronickidney disease,CKD)患者中,骨折的发生率与CKD严重程度呈正比例增长[1],在CKD3~4期,骨折发生率较对照组高2~3倍[2]。而透析患者骨折患病率可达10%~40%[2]。来自日本的一项临床流行病学调查[3]表明,维持性血液透析(maintenancehemodia

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