金昌队列单抗HB-s阳性人群肝功酶异常与脂质代谢指标相关性分析

发布时间：2018-02-04 01:46

  本文关键词： 天冬氨酸氨基转移酶类 横断面研究 流行病学方法　出处：《中华疾病控制杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的探讨金昌队列单抗-HBs阳性人群肝功酶异常与脂质代谢指标的关系。方法整群抽取2011年6月~2013年12月进入金昌队列且排除各种肝病史的单抗-HBs阳性者14 467例作为研究对象,通过实验室血清学检测相关酶学及脂质代谢指标。结果该人群丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、谷氨酰转肽酶(gamma-glutamyltransferase,GGT)异常检出率分别为21.35%、17.45%、15.01%,均为男性高于女性(均有P0.001)。趋势性x~2检验分析显示,随着甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)、体质指数(body mass index,BMI)升高,ALT、AST、GGT异常检出率升高(均有P0.001);随着高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)升高,ALT、AST、GGT异常检出率下降(均有P0.001),具有剂量反应关系。尿酸(uric acid,UA)异常组ALT、AST、GGT异常检出率均高于正常组(均有P0.001)。结论金昌队列单抗-HBs阳性人群ALT、AST、GGT异常检出率均为男性高于女性,且与BMI、TG、TC、LDL-C、HDL-C存在剂量反应关系。
[Abstract]:Objective to investigate the relationship between abnormal liver function and lipid metabolism in Jinchang cohort with positive mAb HBs. Methods Cluster sampling from June 2011 to December 2013 entered Jinchang cohort and excluded all kinds of liver disease history. Positive for anti-HBs. 467 cases were studied. Results Alanine aminotransferase (alt) was detected by laboratory serology. Aspartate aminotransferase (AST). The abnormal detection rate of gamma-glutamyltransferase GGTwas 21.35% and 17.45%, respectively. All of them were higher in males than in females (P 0.001). The results of TGs showed that triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-triglyceride-@@. Total cholesterol low density lipoprotein cholesterol. LDL-CU, body mass index (BMI) were increased and the abnormal detection rate of ASTGT was increased (P 0.001). High density lipoprotein cholesterol (HDL-C) increased with high density lipoprotein (HDL-C). The abnormal detection rate of GGT was decreased (P 0.001), which had dose-response relationship. The positive rate of GGT abnormality in Jinchang cohort was higher than that in normal group (P 0.001). Conclusion the positive rate of alt ASTT in Jinchang cohort was higher in males than in females. There was a dose-response relationship between LDL and HDL-C in TGN.
【作者单位】： 兰州大学公共卫生学院流行病与卫生统计学研究所;金川集团股份有限公司职工医院检验科;兰州大学基础医学院医学实验中心;
【基金】：国家医改重大专项 国家重大公共卫生服务项目(财社[2012]64号) 金川有色金属股份有限公司与兰州大学合作项目(金科综2012-13)
【分类号】：R446.1
【正文快照】： (Chin J Dis Control Prev 2016,20(9):893-896)姬晓虹和白亚娜为共同第一作者丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotrans-ferase,AST)、谷氨酰转肽酶(gamma-glutamyltrans-ferase,GGT)是广泛存在于肝脏并能反映肝脏损伤的，

本文编号：1488953