2010-2014年黏液型铜绿假单胞菌药物敏感性及多药耐药菌分析

发布时间：2018-02-16 01:08

本文关键词： 铜绿假单胞菌黏液型药物敏感性多药耐药菌　出处：《中华医院感染学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的分析医院2010-2014年分离出的黏液型铜绿假单胞菌的药物敏感性及多药耐药菌的检出情况,为临床及时、合理用药提供参考依据。方法对分离出的黏液型铜绿假单胞菌进行药物敏感性检测,同时对多药耐药菌的检出率进行统计。结果黏液型铜绿假单胞菌对常见抗菌药物的敏感率均75.0%,对大部分抗菌药物的敏感率逐年下降;与非黏液型铜绿假单胞菌相比,黏液型铜绿假单胞菌的敏感率较高;门诊患者对头孢他啶和环丙沙星的敏感率高于住院患者(P0.05);呼吸内科患者对头孢他啶的敏感率低于其他非呼吸科室(P0.05);多药耐药黏液型铜绿假单胞菌检出率9.0%,泛耐药黏液型铜绿检出率0.9%,均低于非黏液型铜绿假单胞菌。结论黏液型铜绿假单胞菌药物敏感率较高,但呈逐年下降趋势;其多药耐药菌检出率逐年递增;治疗黏液型铜绿假单胞菌感染时应注意其生物膜影响,可联合用药,避免抗菌药物滥用,以减缓多药耐药菌的产生。
[Abstract]:Objective to analyze the drug sensitivity and multidrug resistance of Pseudomonas aeruginosa isolated from 2010 to 2014. Methods the drug sensitivity of Pseudomonas aeruginosa isolated from myxomonas aeruginosa was detected. Results the sensitivity rate of Pseudomonas aeruginosa to common antimicrobial agents was 75.0, and the sensitivity rate to most antimicrobial agents decreased year by year, compared with that of non-mucinous Pseudomonas aeruginosa, and compared with that of non-mucinous Pseudomonas aeruginosa, the sensitivity of Pseudomonas aeruginosa to common antimicrobial agents decreased year by year. The sensitivity of Pseudomonas aeruginosa was higher than that of Pseudomonas aeruginosa. The sensitivity of outpatients to ceftazidime and ciprofloxacin was higher than that of inpatients (P 0.05), the sensitivity of respiratory patients to ceftazidime was lower than that of other non-respiratory departments (P0.05), and the detection rate of multidrug resistant myxomonas aeruginosa was 9.0%. The detection rate of myxotypic Pseudomonas aeruginosa was 0.9, which was lower than that of non-mucinous Pseudomonas aeruginosa. Conclusion the drug sensitivity rate of mucus type Pseudomonas aeruginosa is higher. The detection rate of multidrug resistant bacteria increased year by year, and the biofilm effect should be paid attention to in the treatment of myxomonas aeruginosa infection, which could be used in combination to avoid the abuse of antimicrobial agents in order to slow down the production of multidrug resistant bacteria.
【作者单位】：临沂市人民医院;浙江大学医学院附属第一医院传染病诊治国家重点实验室;日照市莒县中医院;
【基金】：国家自然科学基金资助项目(81400586)
【分类号】：R446.5

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