29770例输血前血型不规则抗体患者调查与分析

发布时间：2018-02-16 21:31

本文关键词： 不规则抗体输血安全微柱凝胶法　出处：《医学研究生学报》2016年03期 　论文类型：期刊论文

【摘要】：目的患者输血前进行不规则抗体筛查可避免免疫性溶血性输血反应的发生。文中分析患者血型不规则抗体分布情况,确保安全输血提供依据。方法选取2012年1月至2015年8月间在南京军区南京总医院拟输血患者29 770例。通过微柱凝胶法进行血型不规则抗体筛查及交叉配血。初筛为不规则抗体阳性患者,再采用谱细胞分析,确定不规则抗体的特异性。结果 29770例患者中有120例抗体阳性,约占0.4%;不规则抗体的种类分别为:Rh系统67例、Lewis系统5例、Kidd系统3例、MNS系统7例、抗体特异性不明确38例;其中女性患者70例,男性患者50例。妊娠史是女性产生不规则抗体的主要原因(65.7%)。结论临床上少数患者存在血型系统不规则抗体,女性患者中尤以有妊娠史者为著。输血前对患者采用微柱凝胶法进行抗体筛查和交叉配血可为患者及时和安全输血提供保障。
[Abstract]:Objective to avoid the occurrence of immune hemolytic transfusion reaction in patients with irregular antibody screening before blood transfusion. Methods from January 2012 to August 2015, 29 770 patients were selected from Nanjing General Hospital of Nanjing military region. Blood group irregular antibody screening and cross matching were carried out by microcolumn gel method. For irregular antibody positive patients, Spectral cell analysis was used to determine the specificity of irregular antibodies. Results among the 29770 patients, 120 were positive, accounting for about 0.4.The types of irregular antibodies were 67 cases of Lewis system, 5 cases of Kidd system and 7 cases of MNS system. The specificity of antibody was unclear in 38 cases, of which 70 cases were female and 50 cases were male. Pregnancy history was the main cause of irregular antibody in women. Microcolumn gel method was used to screen and cross-match antibodies in women, especially those who had a history of pregnancy, which could provide a guarantee for timely and safe blood transfusion.
【作者单位】：南京军区南京总医院输血科;
【基金】：南京军区南京总医院科研基金(2012047)
【分类号】：R457.1

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