安徽省合肥市农村人群睡眠质量与认知功能的相关性研究

发布时间：2018-03-05 19:36

本文选题：匹兹堡睡眠质量指数量表　切入点：认知功能　出处：《安徽医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的越来越多的证据证明中老年人群睡眠质量和认知功能之间存在一定的潜在联系,但是关于失眠以及其他类似睡眠呼吸障碍和生物节律障碍等睡眠问题与认知功能障碍的流行病学研究未能得到一致的结论,同时国内关于此方面的人群研究较少,因此本研究基于此次安徽省人群调查数据探究安徽省合肥市农村中老年人群睡眠质量指数与认知功能之间的关系。方法 2014年5月在安徽省合肥农村地区进行流行病学调查。分别利用匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index, PSQI)以及简易精神状态量表(Mini-mental state examination, MMSE)对人群完成相应睡眠质量和认知功能的测查。同时,本次调查也充分收集评估了各项与睡眠和认知相关联的变量,包括婚姻状况、教育程度、吸烟、体力劳动、血压、空腹血糖、血脂(甘油三酯、低密度脂蛋白、高密度脂蛋白、总胆固醇)、尿素氮、尿酸、肌酐、体重指数(body mass index, BM)、抑郁得分以及营养状况如白蛋白。采用多元线性回归模型分析睡眠质量指数PSQI总得分与认知功能MMSE得分的关系。结果共有777名人群完成所有资料收集,纳入到此次横断面研究。(1)比较研究人群基本特征发现,随着人群PSQI得分的增加,研究人群的年龄、文盲所占比例、尿素氮水平以及体重指数显著性增加(P0.05),高血压比例、抑郁得分以及总胆固醇水平接近统计学意义。另外,本研究人群的高密度脂蛋白水平随着PSQI得分增加而增加,组间差异达到显著性统计学差异(P=0.004)；(2)多元线性回归分析提示,在校正年龄、性别、教育水平、婚姻状况、血压、血糖、血脂、白蛋白、尿酸、尿素氮、肌酐、抑郁得分、体重指数BMI、吸烟史、体力劳动以及既往疾病史等相关危险因素后,以PSQI总得分的第一分位组(25.5±4.7)作为参照,PSQI总得分的第三分位组中人群MMSE得分显著性降低(23.3±5.3,P0.001)；(3)性别分组分析结果显示在女性人群中随着PSQI总得分增加,相应MMSE得分呈显著性降低(β=-0.14,SE=0.05,P=0.004),而在男性人群该关系则不显著(交互作用P=0.093)；(4)年龄分组分析结果显示在年龄大于60岁人群中PSQI总得分与MMSE得分呈显著性负相关(β=-0.19, SE=0.06, P=0.002),而在小于60岁人群中相关性不显著(交互作用P=0.026)。结论本横断面研究发现安徽省合肥市农村地区中老年人群中睡眠质量指数量表总得分与认知功能呈现线性负相关,而且该关系仅在女性人群和老年人群中显著。本研究提示在合肥农村地区中老年人群中睡眠障碍可能是认知功能的一个危险因素,但是本研究结果仍需更多的大样本前瞻性队列研究证实。
[Abstract]:Objective to prove that there is a potential link between sleep quality and cognitive function in middle-aged and elderly people. However, epidemiological studies on sleep problems such as insomnia and other sleep problems such as sleep apnea disorder and biological rhythm disorder and cognitive dysfunction have not reached a consistent conclusion. At the same time, there are few studies on this aspect of the population in China. Therefore, based on the data of population survey in Anhui province, this study explored the relationship between sleep quality index and cognitive function of middle and aged rural population in Hefei, Anhui province. Methods in May 2014, the flow was carried out in rural area of Hefei, Anhui province. The Pittsburgh sleep quality Index (PSQI) and the Mini-mental state examination scale (MMSEI) were used to measure sleep quality and cognitive function. The survey also fully collected and evaluated variables associated with sleep and cognition, including marital status, education, smoking, manual labor, blood pressure, fasting blood glucose, blood lipids (triglyceride, low density lipoprotein, high density lipoprotein), Total cholesterol, urea nitrogen, uric acid, creatinine, Body mass index (BMI), mass index, depression score and nutritional status such as albumin were used to analyze the relationship between total PSQI score of sleep quality index and MMSE score of cognitive function. In this cross-sectional study, the basic characteristics of the study population were compared. It was found that with the increase of PSQI score, the age, illiteracy, urea nitrogen level and body mass index of the study population increased significantly (P 0.05), and the proportion of hypertension increased significantly. The depression score and total cholesterol level were close to statistical significance. In addition, the high density lipoprotein level increased with the increase of PSQI score, and the difference between the two groups was significant. After adjusting for age, sex, educational level, marital status, blood pressure, blood glucose, blood lipid, albumin, uric acid, urea nitrogen, creatinine, depression score, body mass index (BMI), smoking history, physical labor and previous disease history, The MMSE score in the third position group (25. 5 卤4. 7) of the total score of PSQI was significantly decreased by 23. 3 卤5. 3% (P 0. 001)) the results of gender grouping analysis showed that the MMSE score increased with the increase of the total PSQI score in the female population. The corresponding MMSE score was significantly decreased (尾 -0.14 SEP 0.05 P0. 004, but not in the male population.) the age group analysis showed that the total PSQI score was negatively correlated with the MMSE score in those over 60 years of age (尾 -0.19, SE0.06, P0.002, P0.002, P < 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002, P = 0. 002). There was no significant correlation between sleep quality index and cognitive function in the population under 60 years old. Conclusion the overall score of sleep quality index was negatively correlated with cognitive function in the middle aged and elderly population in rural area of Hefei, Anhui Province. This study suggests that sleep disorders may be a risk factor for cognitive function in rural areas of Hefei. However, the results of this study still need to be confirmed by a large sample of prospective cohort studies.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R740

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