人体呼出气中内源性挥发性有机物筛选研究

发布时间：2018-03-06 11:13

本文选题：呼出气　切入点：内源性VOCs　出处：《中国环境科学》2016年10期 　论文类型：期刊论文

【摘要】：人体代谢产生的内源性挥发性有机物(VOCs)可用作健康状况的标志物.本研究选择17~26岁无呼吸系统疾病的高校学生(73人)作为观察对象,使用气相色谱-火焰离子化检测器/质谱联用仪(GC-FID/MS)分析收集到的呼出气样本,对呼出气中VOCs的种类、浓度进行研究,发现了其5种卤代物的浓度高于室内浓度,其次是室外浓度.其中,在人体呼出气中1,1-二氯乙烯的浓度为室内浓度的近20倍,是室外浓度的近300倍,人体呼出气是环境中1,1-二氯乙烯的一个重要源.定量分析健康人呼出气,对比其与环境空气样本的浓度差异,并进行统计学检验,共筛选出1,1二氯乙烯、丙酮、1-己烯、甲基环己烷、2-戊酮、反-2-戊烯、2,4-二甲基戊烷、3-戊酮、四氯乙烯、对二氯苯、间二氯苯11种特征性内源性VOCs.
[Abstract]:The endogenous volatile organic compounds (VOCs) produced by human metabolism can be used as markers of health status. In this study, 73 college students aged 17 to 26 years without respiratory diseases were selected as observation objects. Gas chromatography-flame ionization detector / mass spectrometry was used to analyze the exhalation samples collected by GC-FID / MS. The species and concentration of VOCs in the exhalation were studied. It was found that the concentration of five halogenated compounds was higher than the indoor concentration. The second is outdoor concentration. Among them, the concentration of 1m1-dichloroethylene in human exhaled air is nearly 20 times that of indoor concentration, and 300 times that of outdoor concentration. Human exhalation is an important source of 1-divinyl chloride in the environment. Quantitative analysis of exhalation from healthy people, comparison of the concentration difference between the exhaled air samples and ambient air samples, and statistical test were carried out to screen out 1o 1 dichloroethylene, acetone and 1-hexene. Methyl cyclohexane 2-pentanone, trans--2-pentene-2-dimethylpentane 3-pentanone, tetrachloroethylene, p-dichlorobenzene, m-dichlorobenzene 11 kinds of characteristic endogenous VOCs.
【作者单位】：北京大学环境科学与工程学院环境模拟与污染控制国家重点实验室;
【基金】：科技部支撑计划“区域性大气污染来源识别与预测技术及应用”(2014BAC06B02);科技部重点项目(2015CB553401) 环境模拟与污染控制国家重点实验室专项经费(13Z05ESPCP)
【分类号】：R443

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