压力超负荷左心室肥大过程中兔心电图的变化

发布时间：2018-03-10 14:44

本文选题：兔　切入点：压力超负荷　出处：《郑州大学学报(医学版)》2016年02期 　论文类型：期刊论文

【摘要】：目的:观察压力超负荷左心室肥大(LVH)过程中兔心电图的动态变化。方法:将55只兔随机分为模型组30只和对照组25只。模型组采用肾上腹主动脉次全结扎法制成压力超负荷LVH模型;对照组除不行腹主动脉缩窄外,其余同上。术前及术后2、4、6、8周行心电图检查,测量12导联QRS波振幅、心电轴、QRS波宽度及QTc间期;同时行超声心动图检查测定左心室下壁厚度(LVIW)、左室后壁厚度(LVPW)及室间隔厚度(IVS);术前及术后8周行X线检查测量心胸比值。结果:模型组死亡3只,对照组死亡2只。从术后第4周开始模型组兔LVIW、LVPW及IVS明显增增大并逐渐增加(P0.05),术后第8周心胸比值高于术前(P0.05)。模型组从术后第2周开始,各导联QRS波振幅明显增大并逐渐增加(P0.05);从术后第4周开始QRS波时间、QTc间期和V1~V3导联R/S比值明显增大并逐渐增加(P0.05)。对照组上述指标术前术后无明显变化(P0.05)。结论:压力超负荷LVH过程中兔心电图主要表现为下壁及胸前导联QRS波振幅增大、QRS波时间及QTc间期延长、胸前导联R/S比值增大;心电图的变化早于超声表现,具有一定的早期诊断价值。
[Abstract]:Objective: to observe the dynamic changes of electrocardiogram during left ventricular hypertrophy (LVH) under pressure overload. Methods: 55 rabbits were randomly divided into model group (n = 30) and control group (n = 25). Pressure overload LVH model; In the control group, the abdominal aorta was not constricted, the rest were examined by electrocardiogram before and after operation for 8 weeks, and the amplitude of 12-lead QRS wave, the width of ECG axis and the QTc interval were measured. The left ventricular inferior wall thickness (LVIW), left ventricular posterior wall thickness (LVPWs) and ventricular septal thickness (IVSV) were measured by echocardiography, and the cardiothoracic ratio was measured by X-ray examination before and 8 weeks after operation. Results: three rats died in the model group. From the 4th week after operation, the LVIW PW and IVS of the model group increased significantly and gradually increased P0.05, the ratio of heart to chest at the 8th week after operation was higher than that of the preoperative P0.050.The model group began from the 2nd week after operation. The amplitude of QRS wave in each lead increased obviously and increased gradually (P 0.05), the time interval of QRS wave and the ratio of R / S in lead V1 / V3 increased significantly from the 4th week after operation. In the control group, there was no significant change in the above indexes before and after operation (P 0.05). In the course of LVH, the main manifestation of electrocardiogram was that the amplitude of QRS wave in inferior wall and chest lead increased and the time of QRS wave and QTc interval were prolonged. The ratio of R / S in precordial leads increased, and the change of ECG was earlier than that of ultrasound, so it had some value in early diagnosis.
【作者单位】：郑州大学第一附属医院物理诊断科;
【基金】：河南省卫生厅科技攻关项目2011020016
【分类号】：R540.41;R544.1

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