侵袭性肺炎链球菌感染临床特征与耐药性分析

发布时间：2018-03-12 06:25

本文选题：肺炎链球菌　切入点：侵袭性感染　出处：《中华医院感染学杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的研究侵袭性肺炎链球菌感染的临床特征及耐药性,分析其流行趋势,为有效预防与控制侵袭性肺炎链球菌感染提供依据。方法回顾性调查医院2008年10月-2014年10月非重复分离的41株侵袭性肺炎链球菌感染患者临床资料及药敏试验数据,分析其流行特征及耐药性。结果侵袭性肺炎链球菌感染多发生于内科和儿科病区,以60岁成人和5岁儿童居多,感染季节多在冬春更替期或秋季,感染类型以血液感染为主;41例侵袭性肺炎链球菌感染患者科室分布以内科和儿科为主,分别占58.6%和39.0%;肺炎链球菌对红霉素、四环素和磺胺甲VA唑/甲氧苄啶的耐药率均60.0%,对青霉素G耐药率达31.7%,未发现耐喹诺酮类、利奈唑胺和万古霉素菌株。结论加强侵袭性肺炎链球菌感染患者的目标性监测,明确其耐药特征,有利于预防与控制侵袭性肺炎链球菌感染及流行。
[Abstract]:Objective to study the clinical characteristics and drug resistance of invasive Streptococcus pneumoniae infection and analyze its epidemic trend. Methods the clinical data and drug sensitivity test data of 41 non-repeated isolates of Streptococcus pneumoniae from October 2008 to October 2014 were retrospectively investigated in order to effectively prevent and control the invasive streptococcus pneumoniae infection. Results the most invasive Streptococcus pneumoniae infection occurred in medical and pediatric areas, most of which were 60 years old adults and 5 years old children, and most of the infection seasons were in winter and spring replacement period or autumn. The main types of infection were blood infection. 41 cases of invasive Streptococcus pneumoniae infection were distributed mainly in internal medicine and pediatrics, accounting for 58.6% and 39.0 respectively. The resistance rates of tetracycline and sulfamethazol / trimethoprim were 60. 0 and 31. 7 to penicillin G respectively. No quinolone resistant, linazolamide and vancomycin resistant strains were found. Conclusion the target surveillance of invasive streptococcus pneumoniae infection was strengthened. It is helpful to prevent and control the infection and epidemic of invasive Streptococcus pneumoniae.
【作者单位】：中国医科大学附属第一医院检验科;
【基金】：国家自然科学基金资助项目(81271908)
【分类号】：R446.5

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