3D非刚性运动校正在肝肿瘤动态增强MRI中的应用

发布时间：2018-03-15 06:32

本文选题：肝肿瘤　切入点：肿瘤　出处：《中国医学影像学杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨3D非刚性运动校正在肝肿瘤动态增强MRI(DCE-MRI)中的应用价值。资料与方法回顾性分析2013年1月-2014年11月绍兴市人民医院经病理证实为原发性肝细胞肝癌(HCC)及结直肠癌肝转移的患者37例,分为原发性肝癌组(27例)与结直肠癌肝转移组(10例)。分别对两组患者数据行3D非刚性运动校正,并使用肝脏双血供双室血流动力学Extended Tofts模型计算各组容量转移常数(K~(trans))、速率常数(K_(ep))、血管外细胞外容积分数(V_e)、血浆容积分数(V_p)、肝动脉供血比例(HPI)等定量参数,同时测量病灶面积值,比较各组间运动校正前后腹主动脉和门静脉时间-浓度曲线、病灶面积差异。运用ROC曲线比较各定量参数诊断效能。结果 3D非刚性运动校正后,门静脉时间-浓度曲线具有更好的平滑性。运动校正前后原发性肝癌组K~(trans)值均大于结直肠癌肝转移组,差异有统计学意义(P0.05);运动校正后原发性肝癌组V_p值大于结直肠癌肝转移组,差异有统计学意义(P0.05)。运动校正前K~(trans)值的曲线下面积(AUC)为0.80,阈值为0.18/min,灵敏度为81%;运动校正后K~(trans)的AUC为0.85,阈值为0.20/min,灵敏度为87%。V_p的AUC为0.80,阈值为0.16/min,灵敏度为72%,特异度为89%。结论 3D非刚性运动校正在肝肿瘤DCE-MRI定量灌注中具有一定价值,可提高HCC与结直肠癌肝转移的灵敏度。
[Abstract]:Objective to evaluate the value of 3D nonrigid motion correction in dynamic enhanced MRICE-MRI of liver neoplasms. Data and methods retrospective analysis of HCC and its nodule in Shaoxing people's Hospital from January 2013 to November 2014. 37 patients with liver metastases from rectal cancer, The patients were divided into primary liver cancer group (n = 27) and colorectal cancer liver metastasis group (n = 10). The volume transfer constant, rate constant, extracellular volume fraction (ECV), plasma volume fraction (VPP) and hepatic arterial blood supply ratio (HPI) were calculated by Extended Tofts model. The time-concentration curves of abdominal aorta and portal vein and the difference of focus area were compared between groups before and after motion correction. ROC curves were used to compare the diagnostic efficacy of quantitative parameters. The time-concentration curve of portal vein had better smoothness. Before and after exercise correction, the values of KT in HCC group were higher than those in colorectal cancer group. The difference was statistically significant (P 0.05), the VSP value of primary liver cancer group after exercise correction was higher than that of colorectal cancer liver metastasis group. The area under the curve is 0.80, the threshold is 0.18 / min, and the sensitivity is 81.The AUC of the Kni-Transfer after motion correction is 0.85, the threshold is 0.20 / min, the AUC of sensitivity is 0.80, the threshold is 0.16 / min, the sensitivity is 72 / min, the specificity is 0.20 / min, the sensitivity is 0.80, the threshold is 0.16 / min, the sensitivity is 72 / min, the threshold is 0.20 / min, the sensitivity is 0.20 / min, the sensitivity is 0.80 / min, the sensitivity is 0.16 / min, the sensitivity is 72 / min, and the sensitivity is 0.20 / min, respectively. Conclusion 3D nonrigid motion correction has certain value in DCE-MRI quantitative perfusion of liver tumors. It can improve the sensitivity of HCC and liver metastasis of colorectal cancer.
【作者单位】：绍兴市人民医院(浙江大学绍兴医院)放射科;
【基金】：浙江省自然科学基金(LY16H180006) 浙江省公益性计划(2014C33151) 浙江省医药卫生一般研究计划(2014KYA215);浙江省医药卫生一般研究计划(2016KYB306)
【分类号】：R735.7;R445.2

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