非高血压人群维生素D和甲状旁腺激素与血压的关系

发布时间：2018-03-15 08:23

本文选题：维生素D　切入点：甲状旁腺素　出处：《中国全科医学》2016年18期 　论文类型：期刊论文

【摘要】：目的探讨非高血压人群维生素D和甲状旁腺激素与血压的关系。方法选择2011年3月—2012年8月宁波大学医学院附属医院体检中心参加健康体检的非高血压成年人271例为研究对象。采用酶联免疫吸附试验(ELISA)法测定血清25羟维生素D〔25(OH)D〕水平,电化学发光免疫测定(ECLIA)法测定血清全段甲状房腺激素(i PTH)水平。按照血清25(OH)D水平四分位数将受试者分为4组,即1~16μg/L组(65例)、17~25μg/L组(68例)、26~34μg/L组(66例)、35~65μg/L组(72例)。按照血清i PTH水平四分位数将受试者分为4组,即7.8~34.1 ng/L组(65例)、34.2~48.4 ng/L组(70例)、48.5~60.2 ng/L组(65例)、60.3~109.2 ng/L组(71例)。比较各组受试者年龄、性别、收缩压(SBP)、舒张压(DBP)、高血压前期患病率(pre HBP)、生化常规〔包含总胆红素(TBIL)、清蛋白(ALB)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(γGT)、血尿素氮(BUN)、肌酐(Cr)、血尿酸(BUA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)〕和25(OH)D或i PTH。结果不同25(OH)D水平组间年龄、SBP、DBP、pre HBP、ALB、ALT、Cr、TC、LDL-C、i PTH比较,差异有统计学意义(P0.05)。不同i PTH水平组间年龄、DBP、ALB、25(OH)D比较,差异有统计学意义(P0.05)。25(OH)D水平与年龄、SBP、DBP、pre HBP、γGT、BUA、TC、LDL-C、i PTH呈负相关(P0.05)。i PTH水平与年龄、DBP、pre HBP、TC呈正相关(P0.05)。简单线性回归分析结果显示,25(OH)D水平与SBP、DBP之间存在线性依存关系(P0.05);i PTH水平与DBP之间存在线性依存关系(P0.05)。多元线性回归分析结果显示,在逐渐调整并增加混杂因素后,25(OH)D与血压水平之间依存程度并无明显变化,随着25(OH)D水平的升高,SBP、DBP水平逐渐降低,并且这一趋势不受肝功能、肾功能、血脂、血糖、年龄及性别的影响(P0.05);在逐渐调整并增加混杂因素后,i PTH水平与DBP之间依存程度并无明显变化,随着i PTH水平的升高,DBP水平亦逐渐升高,并且这一趋势不受肝功能、肾功能、血脂、血糖、年龄及性别的影响(P0.05)。结论低25(OH)D水平和高i PTH水平可能是高血压的危险因素。
[Abstract]:Objective to investigate the relationship between vitamin D, parathyroid hormone and blood pressure in non-hypertensive population. Methods 271 healthy adults were selected from the physical examination center of affiliated Hospital of Ningbo University Medical College from March 2011 to August 2012 to study the relationship between vitamin D, parathyroid hormone and blood pressure. Elisa assay was used to determine the serum 25 hydroxyvitamin D ~ (25) OHH ~ (2 +) level. Electrochemiluminescence immunoassay (ECLIA) was used to determine the whole thyroid atrial hormone (PTH). The subjects were divided into 4 groups according to the quartile of serum 25 OHH D level. That is, 65 patients in 16 渭 g / L group were divided into 4 groups according to the quartile of serum I PTH level, 65 patients in 7.834.1 ng/L group (65 cases) and 70 cases in ng/L group (68.5g / 60.2 ng/L). There were 65 cases with 60.3109.2 ng/L and 71 cases in ng/L group. The age, sex, sex of the subjects were compared according to the quartile number of serum I / P / L group (7.834.1 渭 g / L), 65 patients were divided into four groups, namely, 7.834.1 ng/L group (n = 65) with a total of 68.5g / L / L group (n = 65) and 63.109.2 ng/L group (n = 71). The age, sex and sex of the subjects were compared with those of the control group (n = 65). SBP, DBP, pre HBP, biochemistry (including total bilirubin TBILN, Albumin, alanine aminotransferase, 纬 -glutamyltransferase (纬 -GTT), blood urea nitrogen bunn, creatinine Crn, blood uric acid BUAA, total cholesterol TCU, triacylglycerol, triacylglycerol). TGG, HDL-CU, LDL-Cn, FPGN) and 25 OHHHG or I PTHs. Results the results showed that the PTH was compared between the two groups with different levels of 25 OHHD, pre-HBPnb, ALTCL-Con, and FBG, and the results were as follows: (1) the results were as follows: (1) the results showed that there were no significant differences in PTH between the two groups with different levels of TGG, HDL-CU, LDL-Con, and the levels of 25 OHHN, or I PTHN. The difference was statistically significant (P 0.05). There was a negative correlation between the level of P0.05 PTH and the age of SBP0. 05 PTH, 纬 GTBUAT TCU LDL-Cni PTH and the level of P0. 05 PTH. There was a positive correlation between the level of P0. 05 and pre HBPTC. The results of simple linear regression analysis showed that there was a linear relationship between the level of OHH D and the level of DBP. There was a linear relationship between the level of PTH and the level of DBP, and there was a linear relationship between the level of PTH and the level of DBP in the two groups (P 0. 05) and the results of simple linear regression analysis showed that there was a linear relationship between the level of PTH and the level of DBP. The results of multivariate linear regression analysis showed that, After adjusting and increasing the confounding factors, there was no significant change in the degree of dependence between OHD and blood pressure level. With the increase of 25 OHH D level, the DBP level of SBP decreased gradually, and this trend was not affected by liver function, renal function, blood lipid, blood glucose. After adjusting and increasing the confounding factors, there was no significant change in the degree of dependence between I PTH level and DBP, and with the increase of I PTH level, the DBP level increased gradually, and this trend was not affected by liver function and renal function. The effects of blood lipid, blood glucose, age and sex on blood lipids (P 0.05). Conclusion the low level of 25 OHH D and the high level of I PTH may be the risk factors of hypertension.
【作者单位】：宁波大学医学院附属医院心内科;
【分类号】：R446.6

【参考文献】