医院感染鲍氏不动杆菌分布与耐药性分析

发布时间：2018-03-16 04:06

本文选题：鲍氏不动杆菌　切入点：多药耐药菌　出处：《中华医院感染学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的了解医院感染鲍氏不动杆菌的临床分布特点与耐药性,为控制医院感染提供依据。方法收集2011-2013年医院感染实时监控系统,回顾性分析综合医院临床送检标本鲍氏不动杆菌检测结果及其耐药性;采用法国生物梅里埃公司VITKE-2Campact全自动细菌鉴定仪进行菌株鉴定,药敏试验采用K-B纸片琼脂扩散法,使用SPSS 17.0软件进行统计分析。结果 2011-2013年医院住院患者送检标本中检出病原菌25 758株,其中鲍氏不动杆菌2 543株,检出率为9.9%;标本主要来自重症监护病房、呼吸内科、神经内科;鲍氏不动杆菌送检标本分离率居首位的是痰液;临床分离2 543株鲍氏不动杆菌对哌拉西林/他唑巴坦、氨苄西林/舒巴坦、头孢他啶、头孢吡肟、头孢呋辛、头孢噻肟、头孢曲松、亚胺培南、四环素、环丙沙星耐药率80.0%,对庆大霉素和阿米卡星的耐药率分别为79.5%和78.5%;只对少数抗菌药物,如氨苄西林、阿莫西林/克拉维酸、头孢唑林、氨曲南、呋喃妥因的耐药率20.0%。结论综合医院分离鲍氏不动杆菌临床分布主要集中在重症监护病房,其耐药率较高,并且多数呈现广泛耐药,应重视鲍氏不动杆菌感染的预防和监测,并对其耐药机制做进一步研究。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of Acinetobacter baumannii in hospital infection, and to provide a basis for the control of nosocomial infection. The results and drug resistance of Acinetobacter baumannii in clinical samples of general hospitals were analyzed retrospectively, the strains were identified by VITKE-2Campact automatic bacteria identification instrument of French Bio-Merier Company, and the susceptibility test was performed by K-B disk Agar diffusion method. Results from 2011 to 2013, 25 758 strains of pathogenic bacteria were detected, including 2 543 strains of Acinetobacter baumannii, the detection rate was 9. 9%. The highest isolation rate of Acinetobacter baumannii was sputum, and clinical isolation of 2 543 strains of Acinetobacter baumannii against piperacillin / tazobactam, ampicillin / sulbactam, ceftazidime, cefepime, cefuroxime, The resistance rates of cefotaxime, ceftriaxone, imipenem, tetracycline, ciprofloxacin, ciprofloxacin, gentamicin and amikacin were 79.5% and 78.5, respectively; only a few antibiotics such as ampicillin, amoxicillin / clavulanic acid, cefazolin, cefazolin, cefazolin, cefazolin, and cefazolin were resistant to cefotaxime, ceftriaxone, imipenem, tetracycline and ciprofloxacin. Conclusion the clinical distribution of Acinetobacter baumannii isolated in general hospitals is mainly concentrated in intensive care unit, and the drug resistance rate is high, and most of them present extensive drug resistance. Attention should be paid to the prevention and monitoring of Acinetobacter baumannii infection, and the mechanism of drug resistance should be further studied.
【作者单位】：潍坊医学院公共卫生学院;解放军总医院感染管理与疾病控制科;
【基金】：国家自然科学基金资助项目(30872155) 国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”基金资助项(2013ZX10004 805-003) 全军医学科技“十二五”科研基金资助项目(重大专项AWS11L009)
【分类号】：R446.5

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