参附注射液配合西医常规治疗感染性休克的临床疗效

发布时间：2018-03-16 18:34

本文选题：参附注射液　切入点：西医常规治疗　出处：《重庆医学》2016年21期 　论文类型：期刊论文

【摘要】：目的探讨参附注射液配合西医常规治疗感染性休克的临床疗效。方法将2013年3月至2014年9月本院120例感染性休克患者随机分为对照组与观察组,各60例,均行西药常规治疗,观察组加用参附注射液,治疗7d;观察治疗前及治疗24h后两组平均动脉压(MAP)、心率、血乳酸水平、尿量、中心静脉血氧饱和度(Sc-VO2)的改善情况,治疗24、48h后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平;观察48h后外周血管阻力指数(SVRI)、心脏指数(CI)、血管外肺水指数(ELVWI)的改善情况;观察治疗7d后患者病死率、多脏器功能不全发生率及住院时间情况;观察治疗过程中不良反应的发生情况。结果与治疗前比较,两组患者上述各指标均改善;且治疗后观察组TNF-α、IL-6及乳酸水平,以及CI、心率、尿量、MAP、Sc-VO2均优于对照组,差异均有统计学意义(P0.05);其余指标两组间比较,差异均无统计学意义(P0.05);两组患者在治疗过程中均未发现不良反应。结论应用参附注射液治疗感染性休克疗效明显,可改善患者炎性因子与乳酸水平及循环功能,其安全性较高,适合推广使用。
[Abstract]:Objective to investigate the clinical effect of Shenfu injection combined with western medicine in the treatment of septic shock. Methods from March 2013 to September 2014, 120 patients with septic shock in our hospital were randomly divided into control group and observation group. The treatment group was treated with Shenfu injection for 7 days, and the improvement of mean arterial pressure (MAPV), heart rate, blood lactate level, urine volume and central venous oxygen saturation (Sc-VO2) were observed before and 24 hours after treatment. The improvement of peripheral vascular resistance index (SVRI), cardiac index (CI) and extravascular pulmonary water index (ELVWI) were observed 48 hours after treatment, and the mortality was observed 7 days after treatment. The incidence of multiple organ dysfunction and hospitalization time, adverse reactions during treatment were observed. Results compared with those before treatment, the above indexes of the two groups were improved, and the levels of TNF- 伪 IL-6 and lactic acid, CIand heart rate were also improved in the observation group after treatment. The urine volume of MAPSc-VO2 was better than that of the control group, and the difference was statistically significant (P 0.05), and the other indexes were compared between the two groups. No significant difference was found between the two groups in the treatment of septic shock. Conclusion the efficacy of Shenfu injection in the treatment of septic shock is obvious, which can improve the levels of inflammatory factors, lactic acid and circulatory function, and its safety is higher. Suitable for popularization.
【作者单位】：浙江省杭州市淳安县第一人民医院药剂科;浙江省杭州市淳安县第一人民医院重症监护室;
【基金】：2014年浙江省医药卫生一般研究计划项目(2014KYA195)
【分类号】：R459.7

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