维持性血液透析患者缺铁状态与微炎症的相关性研究

发布时间：2018-03-16 20:44

本文选题：维持性血液透析　切入点：缺铁　出处：《中华医院感染学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的探讨维持性血液透析(MHD)患者肾性贫血缺铁状态与微炎症之间的相关性,为临床治疗提供参考依据。方法选取医院2013年1-6月MHD患者54例,将其分为功能性铁缺乏组29例和绝对性铁缺乏组25例,另选30名健康志愿者为对照组,对比分析各组间铁代谢指标、炎性因子的差异;皮尔森相关和逐步回归分析铁代谢指标和炎性指标的相关性。结果功能性铁缺乏组和绝对性铁缺乏组在高敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、铁调素、血清白蛋白(ALB)、二氧化碳结合力(CO2CP)方面比较差异有统计学意义(P0.05);Pearson相关性分析发现铁蛋白(SF)与铁调素、hs-CRP、IL-6呈正相关(r分别为0.64、0.35、0.46,P0.05),与血红蛋白(Hb)、红细胞压积(HCT)、红细胞铁含量、转铁蛋白(TRF)、ALB成负相关(r值分别为-0.48、-0.48、-0.28、-0.43、-0.47,P0.05);铁调素与铁蛋白、IL-6呈正相关(r值分别为0.68、0.34,P0.05);逐步回归分析显示,MHD患者铁蛋白的密切相关因素为Hb、Hs-CRP、铁调素。结论功能性铁缺乏性贫血与微炎症有关;铁调素可反映MHD患者缺铁和炎症状态。
[Abstract]:Objective to investigate the correlation between iron deficiency status and microinflammation in patients with maintenance hemodialysis (MHD). Methods 54 patients with MHD from 2013 to June in our hospital were selected. It was divided into functional iron deficiency group (29 cases) and absolute iron deficiency group (25 cases) and 30 healthy volunteers as control group. Results in the functional iron deficiency group and the absolute iron deficiency group, Gao Min C-reactive protein hs-CRPX, interleukin-6 (IL-6), iron modulin (Ironine), and iron modulin (Ironine) were correlated with Pearson correlation and stepwise regression analysis. There were significant differences in serum albumin (ALBX) and carbon dioxide binding capacity (CO _ 2CP). The correlation analysis showed that the positive correlation between ferritin (SFs) and iron modulin hs-CRP (IL-6) was 0.64 ~ (0.35) ~ 0.56% (P ~ (0.05)), respectively, and there was a significant difference with hemoglobin (HB), hematocrit HCT ~ (+), erythrocyte iron content, and erythrocyte iron content, respectively. The negative correlation value of ALB between TRF and TRFB was -0.48 ~ 0.48 ~ (-0.28) ~ (-0.28) ~ -0.43 ~ (-1) ~ (-0.437) ~ (-1) P 0.05, and the positive correlation between ferritin and ferritin IL-6 was 0.68 ~ (0.34) (P ~ (0.05)) respectively. Stepwise regression analysis showed that the closely related factors of ferritin in MHD patients were Hs-CRPand iron modulin. Conclusion functional iron deficiency deficiency is related to iron deficiency (P < 0.05), and the results of stepwise regression analysis show that the closely related factors of iron protein in MHD patients are Hs-CRPand iron modulin. Blood is associated with microinflammation; Iron modulin can reflect iron deficiency and inflammation in MHD patients.
【作者单位】：中南大学湘雅医学院附属海口医院血液透析科;中南大学湘雅医学院附属海口医院科研处;中南大学湘雅医学院附属海口医院检验科;
【基金】：国家国际科技合作基金资助项目(2013DFA51290) 海口市重点科技计划基金资助项目(2011-SKG-04-116)
【分类号】：R459.5

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