左氧氟沙星使用频度与细菌耐药性的相关性分析

发布时间：2018-03-19 10:24

本文选题：左氧氟沙星　切入点：使用频度　出处：《中华医院感染学杂志》2016年23期 　论文类型：期刊论文

【摘要】：目的分析喹诺酮类抗菌药物左氧氟沙星的使用频度和与临床分离主要细菌耐药性的相关性,为临床合理使用抗菌药物提供参考依据。方法回顾性分析医院2013年1月-2015年6月各季度喹诺酮类药物的使用频度与临床主要分离5种细菌的耐药率,并对二者的相关性进行统计,数据采用SPSS 13.0软件进行统计分析。结果各季度左氧氟沙星的使用DDDs呈升高的趋势,大肠埃希菌随着左氧氟沙星使用频度的增加细菌耐药率逐渐降低,二者呈负相关,差异有统计学意义(P0.05);鲍氏不动杆菌和金黄色葡萄球菌对左氧氟沙星的耐药率呈正相关,肺炎克雷伯杆菌和铜绿假单胞菌对左氧氟沙星耐药率负相关,但差异均无统计学意义。结论大肠埃希菌的耐药率和左氧氟沙星的使用频度具有相关性,要减少多药耐药菌株的产生,应注意合理使用抗菌药物。
[Abstract]:Objective to analyze the frequency of use of levofloxacin (levofloxacin), a quinolone antibiotic, and its correlation with the drug resistance of major clinical isolates. Methods from January 2013 to June 2015, the frequency of use of quinolones and the drug resistance rate of five bacteria were analyzed retrospectively. The data were analyzed by SPSS 13.0 software. Results the DDDs of levofloxacin increased in every quarter. The drug resistance rate of Escherichia coli decreased with the increase of levofloxacin use frequency, and there was a negative correlation between the two, the difference was statistically significant (P 0.05), the resistance rate of Acinetobacter baumannii and Staphylococcus aureus to levofloxacin was positively correlated. There was a negative correlation between Klebsiella pneumoniae and Pseudomonas aeruginosa resistance to levofloxacin, but the difference was not statistically significant. Conclusion there is a correlation between the drug resistance rate of Escherichia coli and the frequency of levofloxacin use. To reduce the production of multi-drug-resistant strains, attention should be paid to the rational use of antimicrobial agents.
【作者单位】：中山大学附属第六医院药剂科;中山大学附属第三医院输血科;中山大学附属第三医院药剂科;
【基金】：国家自然科学基金青年科学基金资助项目(81200094) 高校青年教师培育基金资助项目(13ykpy33)
【分类号】：R446.5

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