血必净注射液对脓毒症患者凝血功能及预后的影响

发布时间：2018-03-21 10:39

  本文选题：血必净注射液　切入点：脓毒症　出处：《中国药房》2016年05期 　论文类型：期刊论文

【摘要】：目的:探讨血必净注射液对脓毒症患者凝血功能及预后的影响。方法:50例脓毒症患者根据入院先后顺序分为对照组与观察组,各25例。对照组患者予常规治疗,观察组患者在常规治疗基础上联合血必净注射液(50 ml,加入5%葡萄糖注射液或0.9%氯化钠注射液250 ml中静脉滴注,bid)治疗,疗程均为7 d。比较两组患者治疗7 d后的凝血功能指标水平、急性生理与慢性健康表(APACHEⅡ)评分及28 d后的病死率。结果:两组患者治疗7 d后的凝血功能各指标较治疗前均明显改善,APACHEⅡ评分较治疗前均明显下降,且观察组改善或下降程度均明显优于对照组,差异有统计学意义(P0.05);随访28 d,观察组患者的病死率为16%,低于对照组(28%),但差异无统计学意义(P0.05)。结论:血必净注射液可通过抑制凝血活化、纠正凝血功能紊乱而改善脓毒症病情的严重程度。
[Abstract]:Objective: to investigate the effect of Xuebijing injection on coagulation function and prognosis of sepsis patients. Methods: according to the order of admission, 50 patients with sepsis were divided into control group and observation group with 25 cases each. The patients in the observation group were treated with 50 ml Xuebijing injection combined with 5% glucose injection or 250ml intravenous infusion of 0.9% sodium chloride injection on the basis of routine treatment. The course of treatment was 7 days. The coagulation function indexes were compared between the two groups after 7 days of treatment. Results: after 7 days of treatment, the indexes of coagulation function in both groups were significantly improved compared with those before treatment, and the scores of Apache 鈪，

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