三维适形放疗中应用榄香烯对食管癌治疗效果的影响

发布时间：2018-03-23 03:20

本文选题：榄香烯　切入点：三维适形放疗　出处：《中国药房》2016年14期 　论文类型：期刊论文

【摘要】：目的:观察三维适形放疗中应用榄香烯对食管癌的效果和安全性的影响。方法:92例食管癌患者按随机数字表法分为研究组50例与对照组42例。对照组患者行三维适形及三野照射治疗,研究组患者在对照组放疗基础上加用榄香烯注射液静脉注射,每次600 mg,qd,持续治疗1个月。观察两组患者治疗1个月后的临床疗效;随访1~3年,计算两组患者的生存率及肿瘤局部控制率;采用生存质量核心问卷(QLQ-C30)和食管癌补充模式表(QLQ-OES18)评价患者的生存质量和症状改善情况;观察两组患者治疗期间不良事件的发生情况。结果:研究组患者的有效率为88.0%,较对照组(66.7%)显著提高,差异有统计学意义(P0.05)。研究组患者随访1、2、3年的的肿瘤局部控制率和生存率较对照组高,但组间比较差异无统计学意义(P0.05)。研究组患者的躯体、情绪、角色、社会、认知功能评分显著高于对照组,疲劳、口干、吞咽梗阻、进食、食欲减退、吞咽困难症状评分显著低于对照组,组间比较差异均有统计学意义(P0.05)。两组患者不良事件发生率比较,差异无统计学意义(P0.05)。结论:榄香烯联合三维适形放疗用于食管癌的近远期疗效确切、安全性高,且有利于提高患者的生存率和生存质量。
[Abstract]:Objective: to observe the effect and safety of elemene in three-dimensional conformal radiotherapy. Methods: 92 patients with esophageal carcinoma were randomly divided into study group (n = 50) and control group (n = 42). Conformal and three-field radiation therapy, The patients in the study group were treated continuously for 1 month by intravenous injection of Elemene injection on the basis of radiotherapy in the control group. The clinical effects of the two groups were observed after one month of treatment. The survival rate and tumor local control rate were calculated, QLQ-C30) and QLQ-OES18 were used to evaluate the quality of life and symptom improvement. Results: the effective rate of the patients in the study group was 88.0, which was significantly higher than that in the control group (66.7%). The local control rate and survival rate of the patients in the study group were higher than those in the control group, but there was no significant difference between the two groups. The body, mood, role and society of the patients in the study group were higher than those in the control group. The score of cognitive function was significantly higher than that of the control group. The scores of fatigue, dry mouth, dysphagia, eating, anorexia and dysphagia were significantly lower than those in the control group, and the differences between the two groups were statistically significant (P 0.05). Conclusion: Elemene combined with three-dimensional conformal radiotherapy is effective and safe in the near and long term of esophageal carcinoma, and it is beneficial to improve the survival rate and quality of life of the patients.
【作者单位】：北京大学人民医院放疗科;福建省肿瘤医院放疗科;
【分类号】：R735.1;R730.55

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