2005—2014年CHINET沙门菌属细菌耐药性监测

发布时间：2018-03-24 03:35

本文选题：沙门菌　切入点：抗菌药物　出处：《中国感染与化疗杂志》2016年03期

【摘要】：目的了解2005年1月—2014年12月CHINET细菌耐药性监测网成员医院临床分离沙门菌属细菌的分布及耐药性。方法对临床分离的沙门菌属细菌,按照统一方案,采用纸片扩散法或自动化仪器法进行药敏试验,结果按CLSI2014年标准判读,数据统计用WHONET5.6进行分析。结果 10年间,沙门菌属细菌的检出率呈上升趋势:2005年为0.2%,2014年为0.7%。3 478株沙门菌属细菌中,鼠伤寒沙门菌954株(27.4%),肠炎沙门菌849株(24.4%)。药敏试验结果显示,沙门菌属细菌对氨苄西林耐药率最高(33.3%~64.8%),对头孢哌酮-舒巴坦、环丙沙星耐药率低,分别为0~5.3%、2.4%~14.3%。鼠伤寒沙门菌耐药率高于伤寒沙门菌、副伤寒沙门菌及肠炎沙门菌,对氨苄西林和甲氧苄啶-磺胺甲唑耐药率高,分别为76.8%和50.5%。多重耐药沙门菌属细菌10年平均检出率为3.9%,2005年检出率最高,为7.5%,2013年检出率最低,为1.5%。结论我国流行的沙门菌属以鼠伤寒沙门菌和肠炎沙门菌为主。鼠伤寒沙门菌的耐药率较高,氨苄西林、甲氧苄啶-磺胺甲唑已不适于临床经验用药。沙门菌属对第三代头孢菌素及喹诺酮类抗菌药物仍维持较高的敏感率,对多重耐药沙门菌属仍需持续行耐药性监测。
[Abstract]:Objective to investigate the distribution and drug resistance of Salmonella bacteria isolated from member hospitals of CHINET bacterial Resistance Surveillance Network from January 2005 to December 2014. The drug sensitivity test was carried out by using disk diffusion method or automatic instrument method. The results were interpreted according to the CLSI2014 year standard, and the data were analyzed by WHONET5.6. The detection rate of Salmonella bacteria showed an upward trend: it was 0.2in 2005, 0.73.478 in 2014, 954 strains of Salmonella typhimurium, and 849 strains of Salmonella enteritis, respectively. The highest resistance rate of Salmonella to ampicillin was 33.34.80.The resistance rate to cefoperazone-sulbactam and ciprofloxacin was low, which was 0.5.32.4cm. The resistance rate of Salmonella typhimurium was higher than that of Salmonella typhimurium, Salmonella paratyphi and Salmonella enteritidis, and the resistance rate of Salmonella salmonella was higher than that of Salmonella typhimurium, Salmonella paratyphi and Salmonella enteritidis. The rates of resistance to ampicillin and trimethoprim sulfamethazole were 76.8% and 50.5%, respectively. The average detection rate of multidrug resistant Salmonella in 10 years was 3.9%, the highest rate was 7.5% in 2005, and the lowest in 2013. Conclusion Salmonella typhimurium and Salmonella enteritidis are the most prevalent salmonella in China. Trimethoprim-sulfamethazol is not suitable for clinical experience. Salmonella is still sensitive to the third generation cephalosporins and quinolones.
【作者单位】：昆明医科大学第一附属医院检验科;复旦大学附属儿科医院;上海交通大学附属儿童医院;北京协和医院;华中科技大学同济医学院附属同济医院;复旦大学附属华山医院;浙江大学附属第一医院;上海交通大学医学院附属瑞金医院;天津医科大学总医院;广州医科大学附属第一医院;新疆医科大学第一附属医院;浙江大学医学院附属邵逸夫医院;甘肃省人民医院;安徽医科大学第一附属医院;北京医院;中国医科大学附属第一医院;四川大学华西医院;内蒙古医科大学附属医院;重庆医科大学附属第一医院;
【分类号】：R446.5

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