不同类型脑膜炎感染患儿脑脊液C-反应蛋白与乳酸相关指标变化分析

发布时间：2018-03-26 07:12

本文选题：脑膜炎感染　切入点：脑脊液　出处：《中华医院感染学杂志》2016年11期

【摘要】：目的研究不同类型脑膜炎感染患儿脑脊液C-反应蛋白(CRP)与乳酸(LA)等相关指标变化及临床意义,为提高确诊率提供依据。方法选取2014年12月-2015年12月医院诊治的67例脑膜炎感染患儿资料进行分析,将其设为试验组,选取同期入院的22例非中枢神经系统疾病患儿设为对照组,采用连续监测酶法、终点比色法以及免疫比浊法检测两组患儿脑脊液中腺苷脱氨酶(ADA)、LA、CRP、乳酸脱氢酶(LDH)的活性,并分析不同类型脑膜炎感染患儿脑脊液CRP、LA等相关指标变化。结果试验组感染患儿脑脊液ADA、LA、CRP、LDH的活性指标,显著高于对照组,差异有统计学意义(P0.05);不同类型脑膜炎患儿ADA、LA、CRP、LDH的活性指标差异有统计学意义(P0.05);病毒性脑膜炎患儿ADA、LA、CRP、LDH的活性指标,显著低于化脓性脑膜炎和结核性脑膜炎患儿,差异有统计学意义(P0.05);受试者工作特征曲线(ROC曲线)下面积大小依次为:ADA、LA、CRP、LDH;ADA指标的敏感性、特异性,均显著高于其他3种活性指标,差异有统计学意义(P0.05)。结论不同类型脑膜炎感染患儿ADA、LA、CRP、LDH的活性指标变化不同,通过联合ADA、LA、CRP、LDH检测,能够对不同类型的脑膜炎患儿进行有效诊断,具有较高的诊断价值,值得推广应用。
[Abstract]:Objective to study the effect of different types of meningitis C- infection in cerebrospinal fluid of children with C-reactive protein (CRP) and lactic acid (LA) changes and other related indicators and clinical significance, and provide evidence for improving the diagnosis rate. Methods from December 2014 -2015 year in December the hospital treated 67 cases of meningitis infection were analyzed, the design for the experimental group, were selected 22 patients with non central nervous system diseases as control group, using continuous monitoring of enzymatic end point colorimetric method and immune turbidimetry detection of two groups of children with adenosine deaminase in cerebrospinal fluid (ADA), LA, CRP, lactate dehydrogenase (LDH) activity, and analysis of different types of CRP infection in cerebrospinal fluid of children with meningitis, change index of LA. The results of the experimental group of ADA infection, cerebrospinal fluid in children with LA CRP, LDH, activity index, was significantly higher than the control group, the difference was statistically significant (P0.05); different types of meningitis in children with ADA, LA, CRP, LDH activity index There are significant differences in standard (P0.05); viral meningitis in children with ADA, LA, CRP, LDH activity index, was significantly lower than that of purulent meningitis and tuberculous meningitis in children, the difference was statistically significant (P0.05); receiver operating characteristic curve (ROC curve) under large area small is as follows: ADA, LA. CRP, LDH; ADA index of sensitivity, specificity, were significantly higher than that of the other 3 active index, the difference was statistically significant (P0.05). Conclusion the different types of meningitis infection in children with ADA, LA, CRP, LDH activity index, through the combination of ADA, LA, CRP, LDH detection, can effectively diagnose the different types of meningitis, which has high diagnostic value, it is worthy of popularization and application.

【作者单位】：郑州大学附属洛阳中心医院检验科;解放军第522医院检验科;
【基金】：河南省科技厅一般基金资助项目(201309877H)
【分类号】：R725.1;R446.14

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