血脂快速分析仪检测血脂的可靠性研究

发布时间：2018-03-27 18:07

本文选题：血脂异常　切入点：床旁检测　出处：《北京大学学报(医学版)》2016年03期

【摘要】：目的:评价血脂快速分析仪Cardio Chek PA(CCPA)快速检测血脂的可靠性。方法:连续收集325例(23~86岁)阜外医院血脂中心入院患者的空腹血样,血清管采集第1份静脉血样并用Beckman分析仪检测血脂各成分,肝素锂管采集第2份静脉血样并使用CCPA分析仪检测,对二者的检测结果进行比较。采用线性回归分析和Bland-Altman法评价两种检测方法获得的总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、甘油三酯(triglycerides,TG)和低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)的相关性。结果:CCPA检测结果与实验室检查结果具有良好的一致性,其TC、HDL-C、TG和LDL-C的相关系数分别为0.875、0.813、0.910、0.864,对回归方程中的变量有无回归关系进行方差分析,P均0.001。两种检测方法检测TC、HDL-C、TG和LDL-C的临床一致百分比分别为97.0%、92.9%、92.4%和83.7%,两种检测方法血脂异常的检出率在TC、HDL-C和TG中没有统计学差异。结论:在严格控制血样采集质量的基础上,CCPA快速血脂检测系统与实验室常规检测法具有良好相关性,是一种可靠的床旁临床血脂筛查工具。
[Abstract]:Objective: to evaluate the reliability of rapid detection of blood lipids by Cardio Chek PA-CCPA. Methods: fasting blood samples were collected from 325 patients admitted to Fuwei Hospital. The first venous blood sample was collected from the serum tube and each component of blood lipid was detected by Beckman analyzer. The second venous blood sample was collected from the heparin tube and detected by CCPA analyzer. The results of the two tests were compared by linear regression analysis and Bland-Altman method. The total cholesterol cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglycerides (TGG) and low density lipoprotein cholesterol (density) were evaluated by means of linear regression analysis and Bland-Altman method. The correlation between lipoprotein-cholesterol and LDL-C.Results the results of the 20% CCPA test were in good agreement with the results of laboratory tests. The correlation coefficients of TG and LDL-C were 0.8750.130.910100.864, respectively. The variance analysis of the variables in the regression equation was conducted by ANOVA (P = 0.001). The clinical consistent percentages of the two methods for the detection of TG and LDL-C were 97.092. 992. 4% and 83. 7%, respectively. There was no statistical difference in the detection rate of abnormal serum lipids between TCX HDL-C and TG. Conclusion: on the basis of strictly controlling the quality of blood sample collection, the CCPA rapid blood lipid detection system has good correlation with the laboratory routine detection method. Is a reliable bedside clinical blood lipid screening tool.
【作者单位】：中国医学科学院阜外医院血脂异常与心血管疾病诊治中心;
【基金】：首都医学发展科研基金(2011400302)资助~~
【分类号】：R446.1

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