654株嗜麦芽窄食单胞菌的分布及耐药性分析

发布时间：2018-04-02 02:04

本文选题：嗜麦芽窄食单胞菌　切入点：分布　出处：《现代预防医学》2016年15期

【摘要】：目的了解南京医科大学附属无锡市人民医院嗜麦芽窄食单胞菌的分布及耐药性,为临床经验性抗感染治疗提供参考。方法对2011年1月-2015年12月分离的嗜麦芽窄食单胞菌进行细菌鉴定及药敏分析,使用WHONET 5.4进行统计分析。结果共分离到35 095株革兰阴性杆菌,其中嗜麦芽窄食单胞菌654株,占1.86%。60岁及以上老年患者分离435株,占66.51%;18~59岁患者分离207株,占31.65%;小于18岁的患者分离12株,占1.84%。标本来源前4位依次是痰液、尿液、血液和咽拭子,分别占81.65%、7.34%、3.67%及2.75%。菌株主要分布于重症医学科、血液科、老年科和呼吸内科,检出率分别为24.77%、22.02%、19.27%及11.01%。5年间该菌对左氧氟沙星、哌拉西林/他唑巴坦、环丙沙星、复方新诺明敏感,耐药率低于20.00%;对头孢他啶耐药率为24.62%~29.38%。结论嗜麦芽窄食单胞菌主要来源于呼吸道标本,且多见于60岁及以上老年患者。5年间嗜麦芽窄食单胞菌总体耐药率变化不大,左氧氟沙星、哌拉西林/他唑巴坦、环丙沙星、复方新诺明及头孢他啶可用作治疗该菌感染的经验用药。
[Abstract]:Objective to investigate the distribution and drug resistance of Stenotrophomonas maltophilia in Wuxi people's Hospital affiliated to Nanjing Medical University. Methods bacterial identification and drug sensitivity analysis of Stenotrophomonas maltophilia isolated from January 2011 to December 2015 were carried out. The results showed that 35 095 strains of Gram-negative bacilli were isolated. Among them, 654 strains of Stenotrophomonas maltophilia were isolated from patients aged 1.86.60 and above, 207 strains were isolated from patients aged 1859 years old, 207 strains were isolated from patients aged 1859 years, 12 strains were isolated from patients younger than 18 years old, accounting for 1.84B. the top four samples were sputum, urine, blood and throat swabs. The strains were mainly distributed in the departments of intensive Medicine, Hematology, Geriatrics and Respiratory Medicine. The positive rates of the bacteria were 24.7770.22 (19.27%) and 11.01.5 (P < 0.01), respectively. The strains were sensitive to levofloxacin, piperacillin / tazobactam, ciprofloxacin, compound sulfamethoxacin, and compound sulfamethoxacin, respectively, and were sensitive to levofloxacin, piperacillin / tazobactam, ciprofloxacin. The rate of drug resistance to ceftazidime was 24.62or 29.38%. Conclusion the Stenotrophomonas maltophilia mainly originated from respiratory tract specimens, and the overall drug resistance rate of Stenotrophomonas maltophilia in patients aged 60 years or older had little change during the period of 5 years. Piperacillin / tazobactam ciprofloxacin compound sulfamide and ceftazidime can be used as experiential agents in the treatment of the bacterial infection.
【作者单位】：南京医科大学附属无锡市人民医院;
【基金】：无锡市科技发展基金(CSE31N1503)
【分类号】：R446.5

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