广谱抗菌药物防治造血干细胞移植后的早期感染

发布时间：2018-04-03 08:48

本文选题：造血干细胞　切入点：干细胞移植　出处：《中国组织工程研究》2016年45期

【摘要】：背景:造血干细胞移植后急性移植物抗宿主病的发生与感染有复杂的关系,控制感染能降低移植相关死亡率。目的:探讨广谱抗菌药物对造血干细胞移植后早期感染发生的影响。方法:收集31例行造血干细胞移植患者的临床资料,均接受自体外周血干细胞移植治疗。外周血干细胞移植后早期(30 d以内),统计观察移植后早期感染发生率和感染类型以及病原菌分布情况、治疗与转归。结果与结论:(1)所有患者均顺利接受自体外周血干细胞移植治疗,造血干细胞移植后早期感染发生率为71%,未出现死亡病例;(2)共检出20株病原菌,其中革兰阴性菌占80%;(3)感染后外周血中性粒细胞数量与感染持续时间均有显著性相关性,差异有显著性意义(P0.01);(4)试验结果表明,造血干细胞移植后早期感染发生率较高,与中性粒细胞减少及恢复时间密切相关。宜在早期选择合适的广谱抗菌药物进行经验性用药,以快速、有效的控制感染。
[Abstract]:Background: acute graft-versus-host disease after hematopoietic stem cell transplantation has a complex relationship with infection.Objective: to investigate the effect of broad-spectrum antibiotics on early infection after hematopoietic stem cell transplantation.Methods: 31 patients with hematopoietic stem cell transplantation received autologous peripheral blood stem cell transplantation.The incidence of early infection, the type of infection, the distribution of pathogens, the treatment and the outcome of peripheral blood stem cell transplantation were statistically observed within 30 days after transplantation.Results and conclusion all patients received autologous peripheral blood stem cell transplantation successfully. The incidence of early infection after hematopoietic stem cell transplantation was 71.There was a significant correlation between the number of neutrophils in peripheral blood and the duration of infection. The results showed that the incidence of early infection after hematopoietic stem cell transplantation was higher than that after hematopoietic stem cell transplantation.It is closely related to neutropenia and recovery time.Appropriate broad-spectrum antimicrobial agents should be selected in the early stage for empirical use in order to control infection quickly and effectively.
【作者单位】：西南医科大学附属医院ICU;
【分类号】：R457.7

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