64例替加环素耐药肺炎克雷伯杆菌感染临床分析

发布时间：2018-04-03 14:25

本文选题：替加环素耐药　切入点：肺炎克雷伯杆菌　出处：《浙江大学》2015年硕士论文

【摘要】：目的探讨替加环素耐药肺炎克雷伯杆菌感染(Tigecycline-resistant Klebsiella pneumoniae, TRKp)的临床特点、易感因素及防治措施。方法对2012年12月到2014年5月期间,我院各病区住院患者分离培养到TRKp并临床诊断为相关系统感染的病例资料进行系统性回顾性分析。结果共183例肺炎克雷伯杆菌感染患者,替加环素耐药64例(35.0%)；耐药者平均年龄60.5±17.6岁；中位住院时间37天。替加环素耐药者中46例(71.9%)为肺部感染,37例(57.8%)耐药前曾使用碳青霉烯类抗生素,57例(89.1%)留置导尿管,19例(29.7%)耐药者合并有脑血管病。有25例(39%)耐药者病情发生恶化及死亡。结论替加环素耐药肺炎克雷伯杆菌的产生与住院时间、感染部位、抗生素的使用、侵入性操作及基础疾病等均相关,病死率高,临床工作应注意防范,以尽可能减少替加环素耐药肺炎克雷伯杆菌感染的产生。
[Abstract]:Purpose

To investigate the clinical characteristics , susceptibility factors and control measures of tegastigmine - resistant Klebsiella pneumoniae ( TRK ) .

method

During the period from December 2012 to May 2014 , a systematic retrospective analysis was performed on the case data for the isolation and culture of the patient from each hospital in our hospital and the clinical diagnosis of the associated system infection .

Results

In total 183 cases of Klebsiella pneumoniae infection , 64 cases ( 35.0 % ) were resistant to tigecycline .
The mean age of drug - resistant was 60.5 卤 17.6 years .
The median hospitalization time was 37 days . 46 of tigecycline - resistant patients ( 71.9 % ) were lung infections , 37 ( 57.8 % ) were resistant to antibiotics before drug resistance , 57 ( 89.1 % ) were indwelling urinary catheters , 19 ( 29 . 7 % ) resistant patients had cerebrovascular diseases .

Conclusion

The production of tigecycline - resistant Klebsiella pneumoniae is related to the hospitalization time , the site of infection , the use of antibiotics , the invasive operation and the underlying diseases , etc . , the mortality rate is high , the clinical work should pay attention to prevention , so as to minimize the production of tegastigecycline - resistant Klebsiella pneumoniae infection .

【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R446.5

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