不同营养支持途径补充谷氨酰胺对重症急性胰腺炎患者血清蛋白水平的叠加效应

发布时间：2018-04-05 18:00

本文选题：急性胰腺炎　切入点：谷氨酰胺　出处：《第三军医大学学报》2016年03期

【摘要】：目的探讨在静脉补充常规剂量谷氨酰胺的基础上,管饲补充一定剂量的谷氨酰胺对重症胰腺炎(severe acute pancreatitis,SAP)患者血清蛋白水平改善有无叠加效应。方法将92例SAP患者按随机数字表法分成病例组和对照组,每组46例。患者均在入院48~72 h内给予营养支持,病例组静脉常规补充谷氨酰胺双肽20 g/L(谷氨酰胺13.25 g),再管饲营养液(谷氨酰胺2.5 g/125 m L);对照组仅静脉常规补充谷氨酰胺。观察2组患者营养支持前后的总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HGB)、总淋巴细胞计数(TLC)等指标的变化情况。结果与对照组相比,病例组患者血清中ALB、PA、TLC明显升高(P0.05),HGB降低明显减少(P0.05)。结论在静脉常规补充谷氨酰胺的基础上,管饲一定剂量谷氨酰胺可以产生增加蛋白合成的叠加效应。
[Abstract]:Objective to investigate the superposition effect of intravenously supplemented glutamine on serum protein level of severe acute patients with severe pancreatitis.Methods 92 patients with SAP were randomly divided into two groups (46 cases in each group).All the patients were given nutritional support within 48h after admission. The patients in the case group were given 20 g / L glutamine dipeptide (13.25 g / L glutamine 13.25 g / L) intravenously, and then intravenously supplemented with glutamine (2.5 g / 125 mL / L glutamine) in the control group.The changes of total protein (TPN), Albumin (ALB), prealbumin (PAA), hemoglobin (HGB) and total lymphocyte count (TLC) before and after nutritional support were observed in the two groups.Results compared with the control group, the serum levels of TLC in the case group were significantly higher than those in the control group, and the decrease of HGB was significantly lower than that of the control group.Conclusion on the basis of routine supplementation of glutamine intravenously, a certain dose of glutamine could increase protein synthesis.
【作者单位】：第三军医大学新桥医院营养科;第三军医大学新桥医院消化内科;
【分类号】：R459.3

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