认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗效观察

发布时间：2018-04-07 14:56

本文选题：认知催眠疗法　切入点：癌因性疲乏　出处：《山东大学学报(医学版)》2016年07期

【摘要】：目的探讨认知催眠疗法在减轻胃癌患者化疗所致癌因性疲乏中的应用效果。方法将60例符合标准的胃癌化疗患者随机分为观察组和对照组,每组30例。2组患者均施行FOLFOX4方案化疗。于化疗第1天开始观察组给予认知催眠疗法,对照组给予常规健康教育,1次/d,每个化疗周期2次。于每周期化疗前、化疗结束后第5天和全部化疗结束后2个月分别评价2组患者的FACIT-F得分及TNF-α、IL-1β、IL-6水平。结果化疗前2组患者疲乏程度相当,FACIT-F评分无统计学差异(P0.05)。化疗后2组FACIT-F评分呈下降趋势,对照组下降更明显,差异有统计学意义(P0.01);2组TNF-α、IL-1β、IL-6水平呈增加趋势,对照组增加更明显,差异有统计学意义(P0.01)。化疗结束后2个月观察组FACIT-F评分及TNF-α、IL-1β、IL-6水平仍高于对照组,差异具有统计学意义(P0.05)。结论认知催眠疗法能够降低TNF-α、IL-1β、IL-6水平,明显改善胃癌化疗患者癌性疲劳,有望成为化疗所致癌因性疲乏的一种新的辅助治疗手段。
[Abstract]:Objective to investigate the effect of cognitive hypnotherapy on relieving carcinogenic fatigue in patients with gastric cancer.Methods 60 patients with gastric cancer were randomly divided into observation group and control group. 30 patients in each group were treated with FOLFOX4 regimen.On the first day of chemotherapy, the observation group was given cognitive hypnotherapy, and the control group was given routine health education once a day, twice a chemotherapy cycle.The FACIT-F score and TNF- 伪 IL-1 尾 IL-6 level were evaluated before each cycle of chemotherapy, 5 days after the end of chemotherapy and 2 months after the end of all chemotherapy.Results there was no significant difference in FACIT-F score between the two groups before chemotherapy (P 0.05).After chemotherapy, the FACIT-F scores of the two groups showed a downward trend, especially in the control group. The difference was statistically significant (P 0.01). The level of IL-1 尾 -IL-6 in the two groups was increased, and the increase was more obvious in the control group (P 0.01).Two months after chemotherapy, the FACIT-F score and the level of IL-1 尾 -IL-6 in the observation group were still higher than those in the control group, and the difference was statistically significant (P 0.05).Conclusion Cognitive hypnotherapy can reduce the level of TNF- 伪 IL-1 尾 and IL-6 and improve cancer fatigue in patients with gastric cancer. It is expected to be a new adjuvant therapy for carcinogenic fatigue in chemotherapy.
【作者单位】：潍坊医学院附属医院消化科;
【分类号】：R473.73

【相似文献】