惠州地区无偿献血者Mur血型检索库的建立

发布时间：2018-04-12 16:11

本文选题：Mur抗原 + 抗-Mur　；参考：《中国输血杂志》2016年02期

【摘要】：目的通过对惠州地区无偿献血者抗-Mur及Mur抗原进行检测,了解其在人群中的分布,建立本地区的Mur血型检索库。方法分别采用高通量微板法和微柱凝胶法对献血者进行抗-Mur筛查和确认,并对其Mur抗原进行血清型检测。根据检测结果及献血者相关资料,建立Mur血型检索库,指导临床用血及献血者招募。结果总筛查人数32 305人,抗体阳性104人,阳性率0.32%,其中41例具有临床意义,男女间的差异具有统计意义(P0.05),女性高于男性;抗原阳性1 862人,阳性率为5.76%。在近1年的临床输血应用中,共避免41袋含有抗-Mur血液流入临床,并为5例抗-Mur阳性患者找到相合血液。结论 Mur血型检索库的建立,能有效避免含有Mur抗体的血液制品流入临床,减少因此引起的疑难配血及输血不良反应,并快速找到相合血源,同时有利于稀有血型献血者的保留和电子配血的开展及推广。
[Abstract]:Objective to investigate the distribution of anti -Mur and Mur antigens in free blood donors in Huizhou area and to establish the Mur blood group retrieval library in Huizhou area.Methods High throughput microplate method and microcolumn gel method were used to screen and identify blood donors against Mur and their Mur antigens were detected.Results the total screening population was 32 305 and the antibody positive rate was 0. 32%. Among them, 41 cases had clinical significance. The difference between male and female was statistically significant (P 0. 05%), and the positive rate of antigen was 5. 76% in 1 862 cases (P 0. 05%) and in 1 862 cases (P 0. 05%).A total of 41 bags containing anti--Mur blood were avoided in clinical blood transfusion for nearly one year and matched blood was found in 5 patients with anti-Mur positive.Conclusion the establishment of Mur blood group retrieval bank can effectively avoid the flow of blood products containing Mur antibody into clinical practice, reduce the adverse reactions caused by difficult matching and transfusion, and quickly find the compatible blood source.At the same time, it is beneficial to the preservation of rare blood group donors and the development and promotion of electronic blood matching.
【作者单位】：汕头大学医学院;惠州市中心血站;
【基金】：惠州市科技局2015年医疗卫生计划项目(2015Y123)
【分类号】：R446.6

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