妇科恶性肿瘤患者医院感染病原菌分布与耐药性分析

发布时间：2018-04-17 22:21

本文选题：恶性肿瘤 + 妇科　；参考：《中华医院感染学杂志》2016年03期

【摘要】：目的探讨妇科恶性肿瘤患者术后医院感染的发生,并对病原菌分布及耐药性进行分析。方法选取2011年1月-2015年7月在医院接受手术治疗的妇科恶性肿瘤患者452例,病原菌的定量培养基菌种的鉴定均根据《全国临床检验操作规程》中与临床微生物学检验相关的规则,应用常规操作方法进行;MIC法进行药敏试验。结果 452例患者发生医院感染42例,感染率9.29%;医院感染的主要类型为切口和尿路感染,分别占47.62%和28.57%;检出病原菌118株,其中革兰阴性菌占72.04%,以大肠埃希菌、铜绿假单胞菌及鲍氏不动杆菌为主,革兰阳性菌占25.42%,以金黄色葡萄菌为主,真菌占2.54%;铜绿假单胞菌及鲍氏不动杆菌对≥3种抗菌药物的耐药率达50.00%;金黄色葡萄菌与表皮葡萄球菌对青霉素的耐药率均达到100.00%,对利福平及万古霉素的耐药率均为0。结论妇科恶性肿瘤患者术后医院感染的主要类型为切口和尿路感染居多,病原菌主要以革兰阴性菌为主,具有较高的耐药性,在治疗时应根据药敏试验结果合理使用抗菌药物。
[Abstract]:Objective to investigate the occurrence of nosocomial infection in patients with gynecological malignant tumor after operation, and to analyze the distribution of pathogenic bacteria and drug resistance.Methods from January 2011 to July 2015, 452 patients with gynecological malignancy received surgical treatment in hospital.In accordance with the rules related to clinical microbiological examination, the identification of pathogenic bacteria in the quantitative culture medium was carried out by using the routine method of MIC method for drug sensitivity test according to the rules of the National procedure for Clinical examination.Results 42 cases of nosocomial infection occurred in 452 patients, the infection rate was 9.29. The main types of nosocomial infection were incision infection and urinary tract infection, accounting for 47.62% and 28.57%, respectively. 118 strains of pathogenic bacteria were detected, of which 72.044 were Gram-negative bacteria, among which Escherichia coli was the main type of nosocomial infection.Pseudomonas aeruginosa and Acinetobacter baumannii were the main bacteria, Gram-positive bacteria were 25.42 and grapevine aureus were the main bacteria.The resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii to more than 3 antimicrobial agents was 50.00.The resistance rate of Grape aureus and Staphylococcus epidermidis to penicillin reached 100.000.The resistant rate to rifampicin and vancomycin was 0.Conclusion the main types of nosocomial infection in patients with gynecological malignant tumor after operation are incision and urinary tract infection. The main pathogens are Gram-negative bacteria and have high drug resistance. The antibiotics should be used reasonably according to the results of drug sensitivity test.
【作者单位】：贵州省遵义医学院附属医院妇科;贵州省遵义医学院附属医院肿瘤科;贵州省遵义医学院附属医院检验科;
【基金】：贵州省科技厅联合基金资助项目(黔科合J字LKZ[2011]20)
【分类号】：R446.5

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