小儿呼吸道感染金黄色葡萄球菌的耐药性分析

发布时间：2018-04-21 08:53

本文选题：呼吸道感染 + 金黄色葡萄球菌　；参考：《现代预防医学》2016年06期

【摘要】：目的调查金黄色葡萄球菌在小儿呼吸道标本中的检出情况及耐药特点,为临床治疗提供依据。方法对小儿科2011-2014年4 876份呼吸道标本检出的金黄色葡萄球菌耐药性进行回顾性分析总结;采用法国生物梅里埃公司VITEK-2全自动微生物鉴定仪进行菌株鉴定,K-B法进行药敏试验,结果判断参照美国临床实验室标准化研究所标准;采用WHONET软件进行统计分析。结果共检出448株金黄色葡萄球菌,其中检出耐甲氧西林金黄色葡萄球菌(MRSA)42株,占9.4%。耐药率较高的抗菌药物主要是青霉素G(92.9%)、红霉素(58.0%)、克林霉素(55.1%)、四环素(19.9%)等;MRSA的耐药情况较甲氧西林敏感的金黄色葡萄球菌(MSSA)明显严重,对庆大霉素、环丙沙星、左旋氧氟沙星、莫西沙星、红霉素、克林霉素等耐药性差异有统计学意义(P0.05)。结论小儿呼吸道标本检出的金黄色葡萄球菌以MSSA为主,对大部分的抗菌药物保持较好的敏感性,但其耐药性有上升趋势不容轻视。
[Abstract]:Objective to investigate the detection and drug resistance of Staphylococcus aureus in children's respiratory tract. Methods the drug resistance of Staphylococcus aureus detected from 4876 respiratory tract specimens in pediatrics from 2011 to 2014 was retrospectively analyzed and summarized. Results according to the standards of American Institute of Clinical Laboratory Standardization, WHONET software was used for statistical analysis. Results A total of 448 strains of Staphylococcus aureus were detected, among which 42 strains of methicillin-resistant Staphylococcus aureus were detected, accounting for 9.4%. The main antimicrobial agents with higher resistance rate were penicillin Gf92.9, erythromycin 58.0, clindamycin 55.1m, tetracycline 19.910). The resistance of MRSA to gentamycin, ciprofloxacin, levofloxacin was significantly more serious than that of methicillin-sensitive staphylococcus aureus (MSSAs), and the resistance of MRSA to gentamycin, ciprofloxacin and levofloxacin was significantly higher than that of methicillin-sensitive staphylococcus aureus. The drug resistance of moxifloxacin, erythromycin and clindamycin were significantly different (P 0.05). Conclusion Staphylococcus aureus detected in children's respiratory tract is mainly MSSA and has a good sensitivity to most antimicrobial agents, but the increasing trend of drug resistance should not be ignored.
【作者单位】：南京医科大学附属南京医院(南京临床核医学中心);
【分类号】：R446.5;R725.6

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