血清sFlt-1、PLGF水平及比值变化预测孕妇轻度子痫前期发病的Meta分析

发布时间：2018-04-25 23:36

本文选题：轻度子痫前期 + 胎盘生长因子　；参考：《南京医科大学学报(自然科学版)》2016年10期

【摘要】：目的 :探讨血清可溶性血管内皮生长因子受体-1(soluble fms-like tyrosine kinase-1,s Flt-1)、胎盘生长因子(placental growth factor,PLGF)水平及比值变化与轻度子痫前期发病关系。方法 :检索万方、CNKI、Pub Med、Embase和Cochrane收集1994—2016年国内外公开发表的关于血清s Flt-1、PLGF水平及比值变化与轻度子痫前期关系的中英文病例对照研究,剔除不符合标准的文献,对纳入的文章采用Review Manager 5.3软件对结果进行统计分析。结果:共纳入文献17篇,其中中文文献14篇,英文文献3篇。血清s Flt-1表达水平与轻度子痫前期的关系的异质性检验I~2=96%,P0.000 01,存在明显的异质性,合并效应SMD=4.89(95%CI:3.60~6.17),P0.000 01,差异有统计学意义。血清PLGF表达水平与轻度子痫前期的关系的异质性检验I~2=93%,P0.000 01,存在明显的异质性,合并效应SMD=-2.32(95%CI:-2.91~-1.72),P0.000 01,差异有统计学意义。轻度子痫前期组和正常对照组血清s Flt-1/PLGF比值异质性检验I~2=98%,P0.000 01,合并效应SMD=1.95(95%CI:0.50~3.40),P0.000 01,差异有统计学意义。结论:PLGF与轻度子痫前期的发病具有密切关系,血清s Flt-1的表达水平与轻度子痫前期有关,s Flt-1以及s Flt-1/PLGF比值可以作为辅助诊断轻度子痫前期的有效指标。
[Abstract]:Objective: to investigate the relationship between the level and ratio of soluble fms-like tyrosine kinase-1 (Flt-1) and placental growth factor (PLGF) in patients with mild preeclampsia. Methods: a Chinese and English case-control study on the relationship between serum sFlt-1 PLGF level and its ratio to mild preeclampsia was collected from Cochrane and Pub MedEmbase from 1994 to 2016, and the substandard literature was excluded. The results were analyzed by Review Manager 5.3 software. Results: a total of 17 articles were included, including 14 in Chinese and 3 in English. Heterogeneity of the relationship between the expression of serum s Flt-1 and mild preeclampsia; there was significant heterogeneity in the expression of serum s Flt-1, and there was significant heterogeneity. The combined effect was 4. 8995% CI: 3. 60 ~ 6. 17% P 0. 000 01, and the difference was statistically significant. Heterogeneity test of the relationship between serum PLGF expression level and mild preeclampsia (P 0.00001), there was significant heterogeneity. The combined effect of SMD-2.32A95% CI: -2.91- 1.72P0.00001, the difference was statistically significant. The heterogeneity of serum s Flt-1/PLGF ratio between the mild preeclampsia group and the normal control group (P 0.00001) and the combined effect (SMD-1.95 / 95 CI: 0.50 / 3.40C / P 0.00001) were statistically significant. Conclusion there is a close relationship between the expression of serum s Flt-1 and mild preeclampsia, and the ratio of s Flt-1 and s Flt-1/PLGF can be used as an effective index for the diagnosis of mild preeclampsia.
【作者单位】：苏北人民医院健康管理中心;扬州大学医学院非编码RNA研究中心;苏北人民医院神经内科;昆明理工大学生命科学与技术学院;
【基金】：国家自然科学基金(81471215,81271211) 江苏省社会发展重点病种规范化诊疗项目(BE2015665) 江苏省自然科学基金(BK20151592) 江苏省“333”高层次人才(2013-Ⅲ-0077) 江苏省“六大人才高峰”(2012-ws-002) 扬州市绿扬金凤领军人才(yzlyjfjh2013CX056)
【分类号】：R714.244;R446.1

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