1501份中段尿标本分离病原菌及其耐药性

发布时间：2018-05-04 18:45

本文选题：尿培养 + 病原菌　；参考：《中国感染控制杂志》2016年12期

【摘要】：目的了解某院中段尿标本分离病原菌及其对抗菌药物的耐药性,为临床抗菌治疗提供实验室参考依据。方法对该院2012年10月1日—2015年9月30日临床送检的中段尿标本分离病原菌进行鉴定和药敏试验,应用WHONET 5.6软件对药敏结果进行分析。结果 1 501份中段尿标本共检出病原菌658株,其中革兰阳性菌151株,占22.95%,以凝固酶阴性葡萄球菌和肠球菌为主;革兰阴性菌456株,占69.30%,其中大肠埃希菌占45.44%;真菌51株,占7.75%。病原菌对常用抗菌药物耐药性差异较大,其中大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌中超广谱β-内酰胺酶(ESBLs)菌株的检出率分别为52.84%、41.67%和33.33%,ESBLs菌株的耐药性高于非产超广谱β-内酰胺酶菌株。结论该院中段尿标本分离的病原菌以大肠埃希菌为主,分离菌株对常用抗菌药物耐药严重。
[Abstract]:Objective to investigate the isolation of pathogenic bacteria and their resistance to antimicrobial agents in urine samples in a hospital, and to provide reference for clinical antimicrobial therapy. Methods the pathogenic bacteria isolated from the middle urine samples from the hospital from October 1, 2012 to September 30, 2015 were identified and tested. The results of drug sensitivity were analyzed by WHONET. 6. 6 software. Results A total of 658 strains of pathogenic bacteria were detected in 1 501 urine samples, of which 151 were Gram-positive bacteria (22.95), mainly coagulase negative Staphylococcus and Enterococcus, 456 Gram-negative bacteria (69.30), among which Escherichia coli accounted for 45.4444 and 51 fungi (7.75). The resistance of pathogenic bacteria to common antimicrobial agents is different, among which Escherichia coli, The detectable rates of extended-spectrum 尾 -lactamase (ESBLs) strains in Klebsiella pneumoniae and Proteus mirabilis were 52.84% and 33.33%, respectively. The drug resistance of ESBLs strains was higher than that of non-extended-spectrum 尾 -lactamase producing strains. Conclusion Escherichia coli is the main pathogen isolated from the urine samples in the middle part of the hospital, and the isolates are seriously resistant to common antibiotics.
【作者单位】：滁州市第一人民医院;
【分类号】：R446.12

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