针对脊髓的磁刺激镇痛系统的设计、仿真和实验研究

发布时间：2018-05-05 15:06

本文选题：磁刺激 + 镇痛　；参考：《山东大学》2015年硕士论文

【摘要】：随着社会的发展,我国有逐渐步入老龄化社会的趋势。由各种老年性疾病所引发的疼痛逐渐成为我国社会所面临的普遍问题。现有的镇痛方法包括药物治疗和侵入性手术治疗,都会对患者,特别是老年患者存在或多或少的副作用。本课题在目前相对比较成熟的经颅磁刺激技术的基础上,提出了一种新的镇痛方法：针对脊髓的磁刺激镇痛技术,通过在脊髓部位施加脉冲磁场,抑制乃至阻断疼痛信号的传递。该技术具有无创,非侵入性的特点,对研究治疗老年疼痛性疾病有着十分重要的理论价值和实际意义。本文基于Pspice软件平台,搭建磁刺激系统,仿真磁刺激电路的工作状态和各项性能参数。仿真结果确定磁刺激电路的储能电容值为250μF,耗能电阻值为0.1Ω,线圈电感值为20μH,磁刺激电路的最佳工作状态为欠阻尼状态。根据仿真结果,初步建立110V小电压实验电路,探究磁刺激电路的工作性能。实验测试和分析小电压磁刺激实验系统8字形线圈感应出的磁场在空间的分布形态,实验结果显示：磁场沿x轴分布在原点处呈现一个主峰,在原点两侧大约2.5R处对称出现两个副峰。副峰值约为主峰值的60%；沿y轴和z轴,磁场仅在原点处存在一个峰值,磁场强度从原点向两侧对称衰减。设计电场强度测量装置,测量线圈在磁场主峰和副峰位置处感应出的电场强度,结果显示副峰处电场强度为主峰处的50%。实验进一步测量了皮肤和骨骼对磁场的衰减作用,实验组和对照组的统计学比较结果显示：t检验p值均大于0.05,未发现显著的统计学差异,这说明皮肤和骨骼时并不会对磁场产生明显的衰减。在110V实验电路的基础上,通过仿真电路参数和关键元器件选型,建立800V磁刺激工作系统。测试和分析大电压磁刺激系统8字形线圈产生的磁场强度分布和在人工组织液中产生的电场强度。测量实验结果显示：磁场沿x轴、y轴和z轴的分布形态不变,但加大电压后线圈感应出的磁场强度和电场强度大大增强,在本文中当电压升高8倍左右时,磁场强度值升高了约5倍。沿z轴方向,即磁刺激的有效刺激方向,磁场强度的增加使得线圈的有效刺激深度加大。
[Abstract]:With the development of the society, our country has the tendency to step into the aging society. Pain caused by various senile diseases has gradually become a common problem in our society. Existing analgesic methods, including drug therapy and invasive surgery, have more or less side effects on patients, especially elderly patients. Based on the relatively mature transcranial magnetic stimulation (TMS) technique, a new analgesic method is proposed in this paper. The magnetic stimulation technique is applied to the spinal cord by applying pulsed magnetic field to the spinal cord. Inhibit or even block the transmission of pain signals. This technique has the characteristics of noninvasive and noninvasive, which is of great theoretical and practical significance for the study of the treatment of senile pain diseases. Based on Pspice software platform, a magnetic stimulation system is built to simulate the working state and performance parameters of magnetic stimulation circuit. The simulation results show that the energy storage capacitance of magnetic stimulation circuit is 250 渭 F, the energy dissipation resistance is 0.1 惟, the coil inductance is 20 渭 H, and the optimal working state of magnetic stimulation circuit is underdamping state. Based on the simulation results, a 110 V low voltage experimental circuit is established to explore the performance of magnetic stimulation circuit. The distribution of magnetic field induced by the 8 zigzag coil in the small voltage magnetic stimulation system is measured and analyzed experimentally. The experimental results show that the magnetic field exhibits a main peak at the origin along the x-axis. There are two secondary peaks symmetrically at about 2.5R on both sides of the origin. The secondary peak value is about 60% of the main peak value, and along the y axis and z axis, there is only one peak at the origin, and the magnetic field intensity attenuates symmetrically from the origin to the two sides. An electric field intensity measuring device is designed to measure the electric field intensity induced by the coil at the position of the main peak and the secondary peak of the magnetic field. The results show that the electric field intensity at the secondary peak is 50% of the main peak. The effect of skin and bone on the attenuation of magnetic field was further measured. The results of statistical comparison between the experimental group and the control group showed that the value of p of the test was greater than 0.05, and no significant statistical difference was found. This suggests that skin and bones do not cause significant attenuation of the magnetic field. On the basis of 110V experimental circuit, the 800V magnetic stimulation working system is established through the selection of simulation circuit parameters and key components. The distribution of magnetic field intensity and the electric field intensity in artificial tissue fluid produced by the zigzag coil of high voltage magnetic stimulation system were measured and analyzed. The experimental results show that the distribution of magnetic field along the x axis and z axis is constant, but the magnetic field intensity and electric field intensity induced by the coil are greatly enhanced with the increase of voltage. In this paper, when the voltage is increased about 8 times, The magnetic field intensity is increased about 5 times. Along the z axis, that is, the effective stimulus direction of the magnetic stimulation, the increase of the magnetic field intensity makes the effective stimulation depth of the coil increase.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R402;O441

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