2009～2013年189株嗜水气单胞菌的临床分布与耐药性

发布时间：2018-05-06 02:28

本文选题：嗜水气单胞菌 + 临床分布　；参考：《中国老年学杂志》2016年04期

【摘要】：目的了解本地区临床感染嗜水气单胞菌的分布特点及耐药情况。方法对该院2009~2013年感染性患者标本中分离的嗜水气单胞菌的分布和耐药性进行回顾性分析。结果 5年间共分离到嗜水气单胞菌189株,其中肠道内感染菌株132株,肠道外感染的57株。肠道外感染的菌株多来源于肝胆疾病(20例)、血液系统肿瘤(10例)等患者的血液(26.3%)、胆汁(21.1%)等标本。嗜水气单胞菌的感染多发于夏秋季,50岁以上的中老年人。肠道内与肠道外感染的嗜水气单胞菌的耐药率存在差别,但对氨苄西林、氨苄西林/舒巴坦、头孢唑啉、阿莫西林-克拉维酸、头孢西丁均有较高的耐药率(51.1%),肠道外感染嗜水气单胞菌仅对左氧氟沙星、亚胺培南、阿米卡星、美洛培南较敏感(耐药率10%)。结论该地区嗜水气单胞菌的感染高发于夏秋季、中老年人,以肠道内感染常见,但其对抗菌药物的敏感性较好;肠道外感染多见于肝胆疾病、肿瘤等患者,耐药率较高且在不断上升。临床医师应根据感染部位区别对待,参考药敏选药并继续加强监测。
[Abstract]:Objective to investigate the distribution and drug resistance of Aeromonas hydrophila in clinical infection. Methods the distribution and drug resistance of Aeromonas hydrophila isolated from infectious patients in our hospital from 2009 to 2013 were analyzed retrospectively. Results 189 strains of Aeromonas hydrophila were isolated in the past five years, including 132 strains of enteric infection and 57 strains of extraintestinal infection. Most of the strains of extraintestinal infection originated from the blood samples of 20 patients with hepatobiliary diseases and 10 patients with hematological neoplasms. The infection of Aeromonas hydrophila mainly occurred in the middle and old people over 50 years old in summer and autumn. The drug resistance rates of Aeromonas hydrophila in intestinal tract and extraintestinal infection were different, but ampicillin, ampicillin / sulbactam, cefazolin, amoxicillin-clavulanic acid, ampicillin, ampicillin / sulbactam, amoxicillin-clavulanic acid, The drug resistance rate of cefoxitin was high (51.1%). Aeromonas hydrophila was only sensitive to levofloxacin, imipenem, amikacin and meropenem. Conclusion the infection of Aeromonas hydrophila is more frequent in the summer and autumn in the middle and old people, but its sensitivity to antimicrobial agents is better, and extraintestinal infection is more common in patients such as hepatobiliary diseases, tumors, and so on. The rate of drug resistance is high and rising. Clinicians should be treated differently according to the site of infection, select drugs with reference to drug sensitivity and continue to strengthen monitoring.
【作者单位】：浙江大学医学院;
【基金】：“十二五”国家科技重大专项(2012ZX10004-210)
【分类号】：R446.5

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