比阿培南与其他抗菌药物对某院临床分离致病菌的体外敏感性比较

发布时间：2018-05-06 04:13

本文选题：比阿培南 + 革兰阴性菌　；参考：《中国医院药学杂志》2016年07期

【摘要】：目的:比较研究比阿培南和其他抗菌药物的体外抗菌活性。方法:收集2015年1-5月某院分离的344株临床常见致病菌,采用纸片扩散法测定比阿培南和对照药(美罗培南、亚胺培南、厄他培南、氨曲南、左氧氟沙星、哌拉西林他唑巴坦、头孢他啶和头孢吡肟)对革兰阴性菌的敏感性,及比阿培南和对照药(美罗培南、左氧氟沙星、万古霉素、利奈唑胺、克林霉素、青霉素和呋喃妥因)对革兰阳性菌的敏感性。结果:比阿培南与美罗培南、亚胺培南、厄他培南、哌拉西林他唑巴坦对产和不产ESBL的大肠埃希菌和肺炎克雷伯菌、阴沟肠杆菌及其他肠杆菌的敏感率相仿,且差异无统计学意义(P0.05),但比阿培南对铜绿假单胞菌的敏感率显著高于其他抗菌药物(P0.05);比阿培南与美罗培南对甲氧西林敏感的金葡菌、耐甲氧西林的金葡菌、粪肠球菌和屎肠球菌的敏感率相仿,但显著低于万古霉素、利奈唑胺和呋喃妥因(P0.001)。结论:与其他抗菌药物相比,比阿培南对某院临床分离的革兰阴性菌尤其是铜绿假单胞菌有较高的敏感率,但对鲍曼不动杆菌和肠球菌有较高的耐药率。
[Abstract]:Objective: to compare in vitro antibacterial activity of Biapenem and other antimicrobial agents. Methods: 344 strains of common clinical pathogenic bacteria isolated from January to May 2015 were collected, and biapenem and control drugs (meropenem, imipenem, etapenem, aztreonam, levofloxacin, piperacillin, tazobactam, piperacillin, tazobactam) were determined by disk diffusion method. The sensitivity of ceftazidime and cefepime to Gram-negative bacteria, and to Gram-positive bacteria (meropenem, levofloxacin, vancomycin, linazolamine, clindamycin, penicillin and furantoin). Results: the susceptibility of Biapenem to Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae and other enterobacterias was similar to that of meropenem, imipenem, etapenem, piperacillin, and piperacillin to Escherichia coli and Klebsiella pneumoniae, which produced and did not produce ESBL. There was no significant difference (P 0.05), but the sensitivity rate of Biapenem to Pseudomonas aeruginosa was significantly higher than that of other antimicrobial agents P0.05, and that of Biapenem and meropenem to methoxicillin sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, was significantly higher than that of other antimicrobial agents. The susceptibility rates of Enterococcus faecalis and Enterococcus faecium were similar, but significantly lower than those of vancomycin, linazolamide and furantoin (P 0.001). Conclusion: compared with other antimicrobial agents, Biapenem has a higher sensitivity to Gram-negative bacteria, especially Pseudomonas aeruginosa, but higher resistance to Acinetobacter baumannii and Enterococcus.
【作者单位】：中国药科大学药物代谢动力学研究中心;上海市浦东新区公利医院药剂科;上海市浦东新区公利医院细菌室;
【基金】：上海医院药学科研基金(编号:2013-YY-01-08)
【分类号】：R446.5

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