2012-2014年医院获得性深部真菌感染的临床分布及药敏结果

发布时间：2018-05-06 23:07

本文选题：医院获得性感染 + 真菌　；参考：《现代预防医学》2016年08期

【摘要】：目的对医院获得性深部真菌感染的临床分布及药敏结果进行分析,为临床医院感染防控及合理用药提供依据。方法对2012年1月至2014年12月某三甲医院经实验室证实的深部真菌感染病例检出的真菌菌株信息、药敏结果以及相关临床信息进行收集、整理、分析。结果共检出医院获得性深部真菌267株,来源于264例患者;患者年龄大于60岁占78.11%,死亡34例(病死率为12.88%)。标本来源以血标本(37.08%)与痰标本(34.83%)为主。病例来源前四位的科室为:重症医学科、急诊科、老年病房和血液内科。白色假丝酵母菌对各种抗真菌药物耐药率普遍要低,光滑假丝酵母菌与热带假丝酵母菌对三唑类抗真菌药物均耐药性较高。结论重症医学科、急诊科、老年病房和血液内科是医院获得性深部真菌感染防控的重点科室。目前,真菌耐药的问题没有达到细菌耐药的严重程度,但非白色假丝酵母菌对抗真菌药物的耐药性,尤其是三唑类药物的耐药情况应引起足够关注。
[Abstract]:Objective to analyze the clinical distribution and drug sensitivity of nosocomial deep fungal infection in order to provide evidence for prevention and control of nosocomial infection and rational use of drugs. Methods from January 2012 to December 2014, the information of fungal strains, drug sensitivity and clinical information were collected, sorted and analyzed in laboratory confirmed cases of deep fungal infection in a third Class A Hospital. Results A total of 267 strains of nosocomial deep fungi from 264 patients were found. The age of the patients over 60 years old was 78.11 and the death rate was 34 cases (case fatality rate was 12.88%). Blood samples and sputum samples were mainly collected from blood samples and sputum samples. The top four departments were the Department of intensive Medicine, the Emergency Department, the geriatric ward and the Department of Hematology. The resistance rate of Candida albicans to various antifungal drugs was generally low, and the resistance of Candida smooth and Candida tropicalis to triazole antifungal agents was higher. Conclusion the department of intensive medicine, emergency department, geriatric ward and blood department are the key departments for prevention and control of nosocomial deep fungal infection. At present, the problem of fungal resistance has not reached the level of bacterial resistance, but the resistance of non-Candida albicans to fungal drugs, especially the drug resistance of triazole drugs, should be paid enough attention.
【作者单位】：首都医科大学附属北京友谊医院;
【分类号】：R446.5

【参考文献】