肝细胞性肝癌超声造影定量分析与P53表达相关性研究

发布时间：2018-05-08 00:29

本文选题：肝肿瘤 + 癌　；参考：《中国临床医学影像杂志》2016年01期

【摘要】：目的:探讨肝细胞性肝癌(HCC)中突变型P53蛋白表达与超声造影定量分析参数的相关性。方法 :回顾性分析57例HCC患者超声造影定量分析的各项参数,取得肿瘤组织并用免疫组化染色的方法测定P53蛋白的表达,分析它与造影定量分析参数的相关性。结果:1P53的阳性表达率为54.3%(31/57)。2在P53阳性表达组和阴性表达组中峰值强度、平均渡越时间、达峰时间之间无显著差异(P0.05),而上升斜率、流出时间之间有显著差异(P0.05)。3P53的阳性表达与峰值强度、平均渡越时间、达峰时间无明显相关性(P0.05);P53的阳性表达与上升斜率呈正相关,r=0.377(P0.05),与流出时间呈负相关,r=-0.410(P0.05)。结论 :HCC超声造影参数的上升斜率、流出时间与突变型P53蛋白的表达之间存在一定的相关性,通过时间-强度曲线,可以无创性的评估P53的表达。
[Abstract]:Objective: to investigate the correlation between the expression of mutant p53 protein and the quantitative parameters of contrast-enhanced ultrasound in hepatocellular carcinoma (HCC). Methods: the parameters of ultrasound quantitative analysis in 57 patients with HCC were analyzed retrospectively. The tumor tissues were obtained and the expression of p53 protein was detected by immunohistochemical staining. The correlation between p53 protein expression and quantitative parameters was analyzed. Results there was no significant difference in peak intensity, average transit time and peak reaching time between positive and negative expression groups of 54.3% 54.1 / 57.2, but increased slope. There was significant difference between the outflow time and the positive expression and peak intensity of P0.05U. 3P53. There was no significant correlation between the positive expression of P0.05 + p53 and the rising slope of P0.05. There was a negative correlation between the positive expression of p53 and the outflow time (r-0.410P0.05.) and the positive expression of P0.05was negatively correlated with the outflow time. Conclusion there is a certain correlation between the ascending slope, outflow time and the expression of mutant p53 protein. The expression of p53 can be evaluated noninvasively by time-intensity curve.
【作者单位】：广西中医药大学第一附属医院超声科;广西医科大学第一附属医院;
【基金】：国家自然科学基金(81260222) 广西自然科学基金(2012GXNSFAA276041) 广西卫生厅重点科研项目(桂卫重2011089)
【分类号】：R735.7;R445.1

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