ICU患者感染念珠菌的临床分布及体外药敏分析

发布时间：2018-05-08 17:59

本文选题：重症医学科 + 侵袭性真菌病　；参考：《中华医院感染学杂志》2016年20期

【摘要】：目的了解ICU患者感染念珠菌的临床分布特点及药物敏感性,以指导临床合理使用抗真菌药物减少侵袭性真菌病(IFD)的发生,降低其病死率。方法对2013年1月-2014年12月ICU患者送检5 892份标本中分离出346株念珠菌进行回顾性分析,念珠菌用CHROMagar显色培养基鉴定,疑难菌株用API 20C AUX鉴定板鉴定,采用ATB FUNGUS 3药敏板进行药敏检测。结果从ICU送检的各类标本中分离出念珠菌346株,以白色念珠菌的检出率居首位,检出204株占59.0%,其余为近平滑念珠菌47株占13.6%、热带念珠菌40株占11.6%等;药敏结果显示,5-氟胞嘧啶、两性霉素B对念珠菌属的敏感率高,但唑类药物敏感率在不同种的念珠菌中的体外药敏试验结果有一定的差异。结论必须重视念珠菌的培养鉴定和体外药敏数据分析,合理选用抗真菌药。
[Abstract]:Objective to investigate the clinical distribution and drug sensitivity of Candida infection in patients with ICU, so as to guide the rational use of antifungal drugs to reduce the incidence of invasive mycosis and reduce the mortality. Methods from January 2013 to December 2014, 346 strains of Candida were isolated from 5 892 samples of ICU patients. Candida was identified by CHROMagar medium, and difficult strains were identified by API 20C AUX. ATB FUNGUS 3 plate was used to detect drug sensitivity. Results 346 strains of Candida were isolated from all kinds of specimens submitted for ICU. The detection rate of Candida albicans was the highest, with 204 strains accounting for 59.0%, the remaining 47 strains of Candida tropicalis and 40 strains of Candida tropicalis accounted for 11.6%, respectively. The sensitivity of amphotericin B to Candida is high, but there are some differences in the results of in vitro susceptibility test of azoles in different species of Candida. Conclusion attention should be paid to the culture and identification of Candida and the analysis of drug sensitivity data in vitro and the rational selection of antifungal agents.
【作者单位】：华中科技大学同济医学院附属协和医院检验科;武汉市中心医院检验科;武汉市第一医院皮肤科;武汉市中心医院肾内科;
【基金】：国家自然科学基金项目(81502735) 武汉市科技局青年科技晨光计划项目(2015071704011621) 湖北省自然科学基金项目(2015CFB241)
【分类号】：R446.5

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