血必净联合乌司他汀治疗感染性休克患者的临床疗效观察

发布时间：2018-05-24 08:44

本文选题：血必净 + 乌司他汀　；参考：《中华医院感染学杂志》2016年04期

【摘要】：目的观察血必净联合乌司他汀治疗感染性休克的临床疗效,为今后治疗感染性休克患者提供依据。方法选取2013年1月-2015年6月92例在医院诊治的感染性休克患者进行观察,并按照数字表法随机分为试验组与对照组各46例,对照组给予常规治疗,试验组在对照组的基础上加入血必净联合乌司他汀治疗,观察两组患者的治疗效果、治疗前后的PiCCO测量指数变化(CO、CI、SVR、EVLWI)与血浆脑型利钠肽(BNP)、降钙素原(PCT)以及IL-6浓度,同时观察两组患者的病情变化。结果试验组患者治疗前后的PiCCO测量指数变化,包括:心输出量(CO)、心排血指数(CI)、体循环阻力(SVR)、血管外肺水指数(EVLWI)及BNP、PCT、IL-6变化均显著优于对照组,两组间比较差异有统计学意义(P0.05);试验组患者的治疗总有效率为93.5%;显著优于对照组的82.6%,两组间比较差异有统计学意义(P0.05)。结论血必净联合乌司他汀治疗感染性休克具有较好的临床疗效,能够改善患者病情,提高患者生活质量。
[Abstract]:Objective to observe the clinical effect of Xuebijing combined with ulinastatin in the treatment of septic shock. Methods from January 2013 to June 2015, 92 patients with septic shock were observed and randomly divided into two groups: the experimental group (n = 46) and the control group (n = 46). The experimental group was treated with Xuebijing combined with ulinastatin on the basis of the control group. The therapeutic effect of the two groups was observed. The changes of PiCCO index before and after treatment, plasma brain natriuretic peptide (BNPP), calcitonin protopril (PCT) and the concentration of IL-6 were observed before and after treatment. At the same time, the changes of patients' condition were observed in both groups. Results the changes of PiCCO index before and after treatment in the trial group were significantly better than those in the control group, including cardiac output, cardiac output index, systemic resistance, extravascular pulmonary water index (EVLWI) and IL-6. There was significant difference between the two groups (P 0.05), the total effective rate of the patients in the test group was 93.5%, which was significantly better than that in the control group (82.6%), and the difference between the two groups was statistically significant (P 0.05). Conclusion Xuebijing combined with ulinastatin is effective in the treatment of septic shock and can improve the patient's condition and quality of life.
【作者单位】：南阳市中心医院重症医学科;南阳市中心医院神经外科;南阳市中心医院消化科;郑州大学第一附属医院呼吸内科;
【基金】：河南省医学科技攻关计划基金资助项目(201303660)
【分类号】：R459.7

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