全身炎症反应综合征发病机制理性辨析

发布时间：2018-05-24 16:27

  本文选题：全身炎症反应综合征 + 发病机理　； 参考：《医学与哲学(B)》2016年01期

【摘要】：全身炎症反应综合征是多器官功能障碍综合征的重要病理生理发展过程。全身炎症反应综合征的发生和病理机制尚不十分清楚。目前有三种学说:细胞因子风暴说、正反馈说、促炎/抗炎因子平衡说。本文选择以"平衡论"思想为指导、以"系统论、信息论、控制论"观点假定系统免疫功能保持衡定、以免疫系统功能自身调节代偿为内在动力,对全身炎症反应综合征免疫学发病机制进行哲学探讨,提出了以适应性免疫功能被最大激活为前提,固有免疫功能"代偿/失代偿"的理论观点。
[Abstract]:Systemic inflammatory response syndrome is an important pathophysiological process of multiple organ dysfunction syndrome. The pathogenesis and pathological mechanism of systemic inflammatory response syndrome are not well understood. There are three theories: cytokine storm theory, positive feedback theory and proinflammatory / anti-inflammatory balance theory. This paper chooses the thought of "balance theory" as the guide, and assumes that the immune function of the system is balanced, and the internal power is the self-regulating compensation of the immune system function from the viewpoint of "system theory, information theory, cybernetics". The immunological pathogenesis of systemic inflammatory response syndrome (Sirs) was discussed in philosophy. The theoretical viewpoint of "compensatory / decompensation" of innate immune function was put forward based on the premise of the maximum activation of adaptive immune function.
【作者单位】： 湖南省娄底市中心医院/南华大学附属娄底临床医院/南华大学临床研究生培训基地;
【基金】：2012年娄底市科技局科研基金,项目编号:娄财企指[2012]586
【分类号】：R459.7
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本文编号：1929773