4073对夫妻孕前优生健康检查传染病感染指标及丙氨酸氨基转移酶检测结果分析

发布时间：2018-05-29 08:40

  本文选题：配偶 + 孕前保健　； 参考：《中国全科医学》2016年24期

【摘要】：目的了解孕前夫妻双方乙型肝炎病毒(HBV)、梅毒(TP)、人类免疫缺陷病毒(HIV)的感染状况以及丙氨酸氨基转移酶(ALT)异常率,以便采取有效措施防止夫妻间的相互传播和母婴垂直传播,保障夫妻双方和婴儿健康。方法回顾性选取2012—2014年在河北省妇幼保健中心进行孕前优生健康检查且符合纳入标准的夫妻4 073对为研究对象。收集患者HBV、TP、HIV、ALT检测结果并进行分析。结果 8 146例研究对象中,乙型肝炎病毒表面抗原(HBs Ag)阳性检出率为3.44%(280/8 146),TP快速血浆反应素环状卡片试验(RPR)和TP螺旋体颗粒凝集试验(TPPA)均阳性检出率为0.34%(28/8 146),抗HIV1/2阳性检出率为0,ALT异常检出率为4.82%(393/8 146)。男性HBs Ag阳性、ALT异常检出率大于女性(P0.05)。168例HBs Ag阳性男性中,HBs Ag、乙型肝炎病毒e抗体(HBe Ab)、乙型肝炎病毒核心抗体(HBc Ab)均阳性115例,HBs Ag、乙型肝炎病毒e抗原(HBe Ag)、HBc Ab均阳性23例,其他30例;其配偶HBs Ag、乙型肝炎病毒表面抗体(HBs Ab)、HBe Ag、HBe Ab、HBc Ab均阴性34例。112例HBs Ag阳性女性中,HBs Ag、HBe Ab、HBc Ab均阳性75例,HBs Ag、HBe Ag、HBc Ab均阳性16例,其他21例;其配偶HBs Ag、HBs Ab、HBe Ag、HBe Ab、HBc Ab均阴性13例。28例RPR和TPPA均阳性中,夫妻双方RPR和TPPA均阳性者9对。236例ALT异常男性中,HBs Ag、HBe Ag、HBc Ab均阳性14例;157例ALT异常女性中,HBs Ag、HBe Ag、HBc Ab均阳性7例。≥40岁HBSAg阳性检出率大于20~29岁、30~39岁(P0.05);30~39岁ALT异常检出率大于20~29岁(P0.05)。2014年HBSAg阳性检出率小于2012年、2013年(P0.05);2014年ALT异常检出率小于2012年(P0.05)。结论 HBV、TP在河北省备孕夫妻中均有一定的感染率,ALT异常也有相当的检出率,应对检出患者进行优生优育指导,以有效阻止HBV、TP、HIV在夫妻间的传播和母婴垂直传播,减少出生缺陷、不良妊娠和传染病的发生。
[Abstract]:Objective to investigate the infection status of hepatitis B virus (HBV), syphilis and human immunodeficiency virus (HIV) and the abnormal rate of alanine aminotransferase (alt) between husband and wife before pregnancy so as to take effective measures to prevent the transmission between husband and wife and vertical transmission from mother to child. Protect the health of both husband and wife and the baby. Methods A retrospective study was conducted in Hebei Maternal and Child Health Center from 2012 to 2014. 4 073 couples who met the inclusion criteria were selected as the study subjects. To collect and analyze the results of HIV T T detection in patients with HBV TPS. Results among 8 146 subjects, The positive rate of HBs AgA of HBV surface antigen was 3.44 / 8 / 8 146%. The positive rate of HIV1/2 was 0.34% and 28% 8.146%, respectively. The positive rate of anti-alt was 4.822% 393r / 8.146%. The positive rate of HIV1/2 was 0.34% and 8.146% respectively, and the positive rate of anti-HBs was 3.44 / 8. 146%, and the positive rate of HIV1/2 was 4.822% 393r / 8 146 渭 g / L, and the positive rate of HIV1/2 was 0.34% / 8 146%, while the positive rate of anti-HBs was 3.44%. The positive rate of alt in male patients with HBs Ag was higher than that in female patients with HBs Ag. The positive rate of HBs, HBV e antibody, HBV core antibody and HBc Ab were all higher in males than in females. All of them were positive for HBs, HBe Abs and HBeAg Abs were all positive for HBeAg in 23 cases, and all of them were positive for HBeAg, HBeAg and HBC Abs in all of them, the positive rate of alt was higher in males than in females (P 0.05). In the other 30 cases, the other 30 cases were all negative for HBs, HBs, HBs, HBe and HBc Ab in their spouses. Among the 112 women with positive HBs Ag, all the 75 cases were positive for HBs AgAb, 16 cases were positive for HBs, and 21 cases were for the other 21 cases. His spouse, HBs, HBs, HBe, HBe, HBe, and HBc-Ab were all negative in 13 cases. 28 cases were positive for RPR and TPPA. Both husband and wife were positive for RPR and TPPA in 9 out of 236 men with abnormal ALT. 14 out of 157 women with abnormal ALT were all positive for HBs AgHBeAg HBC Ab. The positive rate of HBSAg in 鈮，

本文编号：1950237